| Project/Area Number |
22790920
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 造血幹細胞 / 非対称分裂 / 単一細胞 / Tie2 / Paired daughter cells / 体外増幅 / Angiopoietin-1 / single cell / 遺伝子 / 移植・再生医療 / 細胞・組織 / 再生医学 / 蛋白質 / 発生・分化 |
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| Research Abstract |
We focused on the distribution of Tie2 on the Pired Daughter Cells(PDCs) of hematopoietic stem cells from the gene expression analysis data. The distribution pattern of Tie2 to PDCs was asymmetrically on steady state, on the other hand, it was symmetrically on the proliferative condition. Moreover, it was suggested that stimulation of Tie2 ligand, Ang-1 shifted the cell division pattern to asymmetric. It will be expected that the operation of cell division pattern of hematopoietic stem cells and stem cell expansion from this research.
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