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Basic research towards the development of therapy and pathogenesis elucidation of Sjogren's syndrome

Research Project

Project/Area Number 22790938
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

ISHINO Hidetaka  京都府立医科大学, 医学(系)研究科(研究院), 講師 (60464583)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords臨床 / 免疫学 / 糖鎖 / シェーグレン症候群 / ムチン / 免疫
Research Abstract

The purpose of this study is to investigate the existence and bioactivity of tumor-associated carbohydrate antigens in Sjogren’s syndrome (SjS).Saliva was collected by the gum test. Labial salivary gland biopsies were obtained in 20 patients. We found that saliva from SjS patients was subjected to gel filtration on Sepharose 6B and collected the fractions including mucins, mucins were strongly expressed in mucous acinar cells and infiltrating mononuclear cells on the labial salivar y gland. Saliva fractions can stimulate the production of TNF-α and PGE2 in human peripheral blood mononuclear cell.This finding suggests that the mucins exhibiting with abnormal glycosylation may be in part responsible for salivary glands inflammation, leading to the salivary glands destruction in the pathogenesis of SjS.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2013

All Presentation (4 results)

  • [Presentation] EXPRESSION OF ABERRANTLY GLYCOSYLATED MUCINS (TN AND SIALYL TN ANTIGENS) AND MUC1 IN LABIAL SALIVARY GLAND OF PATIENTS WITH SJOGREN'S SYNDROME2013

    • Author(s)
      Ishino Hidetaka
    • Organizer
      Annual European Congress of Rheumatology EULAR 2013
    • Place of Presentation
      Madrid Spain
    • Year and Date
      2013-06-13
    • Related Report
      2012 Final Research Report
  • [Presentation] シェーグレン症候群患者唾液腺内での糖鎖の存在証明とその生物学的活性についての検討2013

    • Author(s)
      石野秀岳
    • Organizer
      第57回日本リウマチ学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-04-20
    • Related Report
      2012 Final Research Report
  • [Presentation] EXPRESSION OF ABERRANTLY GLYCOSYLATED MUCINS (TN AND SIALYL TN ANTIGENS) AND MUC1 IN LABIAL SALIVARY GLAND OF PATIENTS WITH SJOGREN’S SYNDROME.2013

    • Author(s)
      HIDETAKA ISHINO
    • Organizer
      Annual European Congress of Rheumatology EULAR 2013
    • Place of Presentation
      Spain Madrid
    • Related Report
      2012 Annual Research Report
  • [Presentation] シェーグレン症候群患者唾液腺内での糖鎖の存在証明とその生物学的活性について の検討2013

    • Author(s)
      石野 秀岳
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      日本 京都
    • Related Report
      2012 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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