Regulation of allergic inflammation by liver X receptor
| Project/Area Number |
22790946
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マスト細胞 / 炎症 / 核内受容体 / アレルギー / アレルギー性炎症 |
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| Research Abstract |
In the present study, we examined the role of liver X receptor(LXR)α and β, which are representative nuclear receptors, on regulation of cytokine production by mast cells. We demonstrated for the first time that activation of LXRα but not LXRβ reppresses IL-1α and IL-1β expression in mast cells. These data suggest that regulation of LXRβ activation may be a useful aproach to reppress mast cell function as inflammatory cells.
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Report
(3 results)
Research Products
(5 results)
