| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Research Abstract |
In the present study, we examined the role of liver X receptor(LXR)α and β, which are representative nuclear receptors, on regulation of cytokine production by mast cells. We demonstrated for the first time that activation of LXRα but not LXRβ reppresses IL-1α and IL-1β expression in mast cells. These data suggest that regulation of LXRβ activation may be a useful aproach to reppress mast cell function as inflammatory cells.
|
