Mucosal-associated invariant T cells in the pathogenesis of arthritis.

• Project/Area Number: 22790950
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: CHIBA Asako 独立行政法人国立精神・神経医療研究センター, 神経研究所免疫研究部, 非常勤研究員 (40532726)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 関節炎 / 自然リンパ球 / マウスモデル / MAIT細胞

Research Abstract

We revealed that Mucosal-Associated Invariant T cells(MAIT cells) promote inflammation and exacerbate arthritis by using two mouse models of arthritis. We also demonstrated that MAIT cells became activated upon stimulation with IL-1βor IL-23 even in the absence of T cell receptor stimuli. These results indicate that MAIT cells may exert different functions depending on the pathologic condition and contribute to augment disease in arthritis models.

Research Products

• [Journal Article] A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation (2012)
  • Author(s): Chiba A, Mizuno M, Tomi C, Tajima R, Alloza I, di Penta A, Yamamura T, Vandenbroeck K, Miyake S
  • Journal Title: Arthritis Res Ther Volume: 14 Issue: 1 Pages: 9-9
  • DOI: 10.1186/ar3683
  • Peer Reviewed
• [Journal Article] Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis (2012)
  • Author(s): Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S
  • Journal Title: Arthritis Rheum Volume: 64 Issue: 1 Pages: 153-161
  • DOI: 10.1002/art.33314
  • Peer Reviewed
• [Journal Article] Innate recognition of cell wallβ-glucans drives invariant natural killer T cell responses against fungi (2011)
  • Author(s): Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levits SM, Brigl M, Brenner MB
  • Journal Title: Cell Host Microbe Volume: 10 Issue: 5 Pages: 437-45
  • DOI: 10.1016/j.chom.2011.09.011
  • Peer Reviewed
• [Journal Article] Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis (2011)
  • Author(s): Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T
  • Journal Title: Int. Immunol Volume: 23 Issue: 9 Pages: 529-535
  • DOI: 10.1093/intimm/dxr047
  • Peer Reviewed
• [Presentation] 自己免疫疾患患者におけるMucosal-associated invariant T細胞の解析 (2012)
  • Author(s): 千葉麻子,田村直人,林絵里,松平蘭,頭山尚子,高崎芳成,三宅幸子
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(港区)
  • Year and Date: 2012-04-26
• [Presentation] 膠原病におけるMucosal-associated invariant T細胞の解析 (2011)
  • Author(s): 千葉麻子,田村直人,松平蘭,高崎芳成,山村隆,三宅幸子
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] 膠原病におけるMucosal-associated invariant T細胞の解析 (2011)
  • Author(s): 千葉麻子,田村直人,松平蘭,頭山尚子,高崎芳成,山村隆,三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会
  • Place of Presentation: 京王プラザホテル(新宿区)
  • Year and Date: 2011-09-17
• [Presentation] マスト細胞の活性阻害を介した関節炎の抑制 (2011)
  • Author(s): 千葉麻子、三宅幸子
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(神戸市)
  • Year and Date: 2011-07-19
• [Presentation] Mucosal associated invariant T cells contribute to the pathogenesis of arthritis. (2010)
  • Author(s): 千葉麻子
  • Organizer: American College of Rheumatology, Scientific Meeting 2010
  • Place of Presentation: アトランタGeorgia World Congress Center
  • Year and Date: 2010-11-11
• [Presentation] Celecoxib analogue lacking COX-2 inhibitory activity inhibits arthritis by suppressing IL-23 and inflammatory cytokines. (2010)
  • Author(s): 千葉麻子
  • Organizer: American College of Rheumatology, Scientific Meeting 2010
  • Place of Presentation: アトランタGeorgia World Congress Center
  • Year and Date: 2010-11-09
• [Presentation] Celecoxib analogue lacking COX-2 inhibitory activity suppresses inflammatory disorders by inhibiting inflammatory cytokines. (2010)
  • Author(s): 千葉麻子
  • Organizer: 10^<th> International Congress of Neuroimmunology
  • Place of Presentation: シッチェスHotel Melia Sitges
  • Year and Date: 2010-10-18
• [Presentation] The role of MR1-restricted MAIT cells in the pathogenesis of murine models of arthritis. (2010)
  • Author(s): 千葉麻子
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸Kobe International Exhibition Hall
  • Year and Date: 2010-08-24
• [Presentation] The role of MR1-restricted MAIT cells in the pathogenesis of murine models of arthritis. (2010)
  • Author(s): 千葉麻子
  • Organizer: FOCiS 2010
  • Place of Presentation: ボストンBoston Marriott Copley Place
  • Year and Date: 2010-06-24
• [Presentation] The role of MR1-restricted MAIT cells in the pathogenesis of murine models of arthritis. (2010)
  • Author(s): 千葉麻子
  • Organizer: EULAR Congress 2010
  • Place of Presentation: ローマFiera Roma
  • Year and Date: 2010-06-19
• [Presentation] 関節リウマチなど関節炎におけるMR1拘束性MAIT細胞の役割 (2010)
  • Author(s): 千葉麻子
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-04-23
• [Presentation] The role of MR1-restricted MAIT cells in the pathogenesis of arthritis. (2010)
  • Author(s): 千葉麻子
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-04-21
• [Remarks] ホームページ等
  • URL: http://www.ncnp.go.jp/nin/guide/r_men/index.html
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r_men/index.html