Mucosal-associated invariant T cells in the pathogenesis of arthritis.
| Project/Area Number |
22790950
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
CHIBA Asako 独立行政法人国立精神・神経医療研究センター, 神経研究所免疫研究部, 非常勤研究員 (40532726)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 関節炎 / 自然リンパ球 / マウスモデル / MAIT細胞 |
|---|
| Research Abstract |
We revealed that Mucosal-Associated Invariant T cells(MAIT cells) promote inflammation and exacerbate arthritis by using two mouse models of arthritis. We also demonstrated that MAIT cells became activated upon stimulation with IL-1βor IL-23 even in the absence of T cell receptor stimuli. These results indicate that MAIT cells may exert different functions depending on the pathologic condition and contribute to augment disease in arthritis models.
|
Report
(3 results)
Research Products
(18 results)
-
-
-
[Journal Article] Innate recognition of cell wallβ-glucans drives invariant natural killer T cell responses against fungi2011
Author(s)
Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levits SM, Brigl M, Brenner MB
-
Journal Title
Cell Host Microbe
Volume: 10
Issue: 5
Pages: 437-45
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
