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Analysis of atopic dermatitis induced bycoenzyme A in mothers' milk, and its development for preventive medicine

Research Project

Project/Area Number 22790997
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionSaitama Medical University

Principal Investigator

HIGASHI Takehiro  埼玉医科大学, 医学部, 客員講師 (00468381)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアトピー性皮膚炎 / Coenzyme A / 母乳 / Th2アジュバント / 樹状細胞 / coenzymeA / CoenzymeA
Research Abstract

The current study showed that some mothers,whose children developed AD, carry high Th2 adjuvant activity in their milk. A low concentration of CoA exhibited Th2 adjuvant activity both in vitro andin vivo. Moreover, mesenteric lymph nodenon-T cells obtained from mice that were orally treated with CoA, led allogeneic naive CD4+T cells to differentiate into Th2. Furthermore, the oral administration of CoA induced atopic dermatitis in mice.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (10 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 母乳中のコエンザイム A とアトピー性皮膚炎2012

    • Author(s)
      東 丈裕、松下 祥
    • Journal Title

      臨床免疫・アレルギ科ー

      Volume: 57(2) Pages: 197-202

    • NAID

      40019209498

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 母乳中のコエンザイムAとアトピー性皮膚炎2012

    • Author(s)
      東 丈裕、松下 祥
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57(2) Pages: 197-202

    • NAID

      40019209498

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and OVA-Ag-induced neutrophilic airway inflammation2011

    • Author(s)
      Nakagome, K., Imamura, M., Okada, H., Kawahata, K., Inoue, T., Hashimoto, K., Harada, H., Higashi, T., Takagi, R., Nakano, K., Hagiwara, K., Kanazawa, M., Dohi, M., Nagata, M., Matsushita, S
    • Journal Title

      J. Immunol

      Volume: 186 Pages: 5975-5982

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Qualitative evaluation of adjuvant activities and its application to Th2/17 diseases2011

    • Author(s)
      Matsushita, S., Takagi, R., Hashimoto, K., Higashi, T
    • Journal Title

      Int. Arch. Allergy Immunol

      Volume: 155(suppl. 1) Pages: 2-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme A contained in mothers` milk is associated with the potential to induce atopic dermatitis2011

    • Author(s)
      Higashi, T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Nakagome, K., Nakamura, K., Kohno, Y. and Matsushita, S
    • Journal Title

      Int. Immunol

      Volume: 23 Pages: 741-749

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Qualitative evaluation of adjuvant activities and its application to Th2/17 diseases2011

    • Author(s)
      Matsushita, S
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: 155 Pages: 2-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and OVA-Ag-induced neutrophilic airway inflammation2011

    • Author(s)
      Nakagome, K
    • Journal Title

      J.Immunol.

      Volume: 186 Pages: 5975-5982

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme A contained in mothers' milk is associated with the potential to induce atopic dermatitis2011

    • Author(s)
      Higashi, T
    • Journal Title

      Int.Immunol.

      Volume: 23 Pages: 741-749

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells2010

    • Author(s)
      Higashi T, Hashimoto K, Takagi R, Mizuno Y, Okazaki Y, Tanaka Y and Matsushita S
    • Journal Title

      Allergology International

      Volume: 59 Pages: 161-166

    • NAID

      10029670257

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Th17 細胞を分化させる諸要因2010

    • Author(s)
      東 丈裕、松下 祥
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53(4) Pages: 407-412

    • NAID

      40017125277

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells.2010

    • Author(s)
      Higashi T
    • Journal Title

      Allergol.Int.

      Volume: 59 Pages: 161-166

    • NAID

      10029670257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblasts stimulated via HLA-II produce PGE 2 and regulate cytokine production from Th cells.2010

    • Author(s)
      Nahoko Kato-Kogoe
    • Journal Title

      Lab Invest.

      Volume: 90 Pages: 1747-1756

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Coenzyme A contained in mothers' milk is associated with the potential to induce atopic dermatitis2011

    • Author(s)
      Higashi, T
    • Organizer
      53rd ASH Annual Meeting and Exposition
    • Place of Presentation
      San Diego Convention Center San Diego (America)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and ovalbumin-antigen induced neutrophilic airway inflammation. ドーパミン D1 受容体拮抗薬は、Th17 型免疫応答を抑制することで、OVA 惹起好中球性気道炎症を抑制する2011

    • Author(s)
      Kazuyuki Nakagome, Mitsuru Imamura, Kimoto Kawahata, Kumiko Hashimoto, Takehiro Higashi, Rie Takagi, Makoto Dohi, and Sho Matsushita
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ドーパミン D1 受容体拮抗薬は Th17 型免疫応答を制御することで OVA 惹起好中球性気道炎症を抑制する2011

    • Author(s)
      中込一之、今村充、岡田浩一、川畑仁人、井上勉、橋本久実子、原田広顕、東丈裕、高木理英、金澤實、萩原弘一、土肥眞、永田真、松下祥
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Coenzyme A contained in mothers` milk is associated with the potential to induce atopic dermatitis Pediatric Allergy and Asthma Meeting 20112011

    • Author(s)
      Sho Matsushita,Naoki Shimojo, Rie Takagi, Yoichi Kohno and TakehiroHigashi
    • Organizer
      Asthma Meeting 2011
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Coenzyme A contained in mothers` milk is associated with the potential to induce atopic dermatitis2011

    • Author(s)
      Takehiro Higashi, Naoki Shimojo, Shuichi Suzuki, Mayuko Nakaya, Rie Takagi, Kumiko Hashimoto, Junichi Tsukada, Koichiro Nakamura, Kazuyuki Nakagome, Yoichi Kohno and Sho Matsushita
    • Organizer
      ^<rd> ASH annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎患児が接種した母乳に含まれる Th2 アジュバント活性物質の同定2010

    • Author(s)
      東丈裕、松下祥
    • Organizer
      第60回日本アレルギー学会秋期学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎患児が接種した母乳に含まれるTh2アジュバント活性物質の同定2010

    • Author(s)
      東丈裕
    • Organizer
      第60回日本アレルギー学会秋期学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coenzyme A concentration in mother's milk predicts the atopic dermatitis-inducing potential in a cohort of Japanese infants.2010

    • Author(s)
      Higashi, T.
    • Organizer
      14TH INTERNATIONAL CONGRESS OF IMMUNOLOGY
    • Place of Presentation
      KOBE
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Curdlan induces DC-mediated Th17 polarisation via jagged1 activation in human deneritic cells2010

    • Author(s)
      Higashi, T., Takagi R., Hashimoto K., Matsushita S
    • Organizer
      The 29th EAACI Congress
    • Place of Presentation
      London, United Kingdom
    • Related Report
      2012 Final Research Report
  • [Presentation] Coenzyme A concentration in mother`s milk predicts the atopic dermatitis-inducing potential in a cohort of Japanese infants2010

    • Author(s)
      Higashi,T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Kohno, Y., Matshishita, S
    • Organizer
      ^<th>International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Book] 臨床免疫・アレルギー科2012

    • Author(s)
      東丈裕
    • Publisher
      母乳中のコエンザイムAとアトピー性皮膚炎
    • Related Report
      2011 Annual Research Report
  • [Book] Th17細胞を分化させる諸要因2010

    • Author(s)
      東丈裕
    • Publisher
      臨床免疫・アレルギー科
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 母乳または飲食品がアトピー性皮膚炎の発症を誘導する危険性を評価する方法、およびアトピー性皮膚炎の発症を誘導する危険性が減少された母乳または飲食品2010

    • Inventor(s)
      松下祥, 東丈裕
    • Industrial Property Rights Holder
      埼玉医科大学(50%)有限会社イムノ(50%)
    • Filing Date
      2010-10-26
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 母乳または飲食品がアトピー性皮膚炎の発症を誘導する危険性を評価する方法、およびアトピー性皮膚炎の発症を誘導する危険性が減少された母乳または飲食品2009

    • Inventor(s)
      松下 祥、東 丈裕
    • Industrial Property Rights Holder
      埼玉医科大学(50%)、有限会社イムノ(50%)
    • Filing Date
      2009-10-29
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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