Analysis of atopic dermatitis induced bycoenzyme A in mothers' milk, and its development for preventive medicine
| Project/Area Number |
22790997
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アトピー性皮膚炎 / Coenzyme A / 母乳 / Th2アジュバント / 樹状細胞 / coenzymeA / CoenzymeA |
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| Research Abstract |
The current study showed that some mothers,whose children developed AD, carry high Th2 adjuvant activity in their milk. A low concentration of CoA exhibited Th2 adjuvant activity both in vitro andin vivo. Moreover, mesenteric lymph nodenon-T cells obtained from mice that were orally treated with CoA, led allogeneic naive CD4+T cells to differentiate into Th2. Furthermore, the oral administration of CoA induced atopic dermatitis in mice.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and OVA-Ag-induced neutrophilic airway inflammation2011
Author(s)
Nakagome, K., Imamura, M., Okada, H., Kawahata, K., Inoue, T., Hashimoto, K., Harada, H., Higashi, T., Takagi, R., Nakano, K., Hagiwara, K., Kanazawa, M., Dohi, M., Nagata, M., Matsushita, S
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Journal Title
J. Immunol
Volume: 186
Pages: 5975-5982
Related Report
Peer Reviewed
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[Journal Article] Coenzyme A contained in mothers` milk is associated with the potential to induce atopic dermatitis2011
Author(s)
Higashi, T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Nakagome, K., Nakamura, K., Kohno, Y. and Matsushita, S
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Journal Title
Int. Immunol
Volume: 23
Pages: 741-749
Related Report
Peer Reviewed
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[Presentation] Coenzyme A contained in mothers` milk is associated with the potential to induce atopic dermatitis2011
Author(s)
Takehiro Higashi, Naoki Shimojo, Shuichi Suzuki, Mayuko Nakaya, Rie Takagi, Kumiko Hashimoto, Junichi Tsukada, Koichiro Nakamura, Kazuyuki Nakagome, Yoichi Kohno and Sho Matsushita
Organizer
^<rd> ASH annual meeting
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Coenzyme A concentration in mother`s milk predicts the atopic dermatitis-inducing potential in a cohort of Japanese infants2010
Author(s)
Higashi,T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Kohno, Y., Matshishita, S
Organizer
^<th>International Congress of Immunology
Place of Presentation
Kobe, Japan
Related Report
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