| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
Fibroblast growth factor 23, FGF receptor, and Klotho is known to participate in homeostasis of phosphate metabolism. To determine the baseline levels of these molecule and their correlation, we measured the serum levels of soluble Klotho in fetuses and compare them with those in neonates, mothers, and adults. In cord blood, the level of Klotho was markedly higher than levels in other samples, whereas the fetal level of FGF23 was lower than levels in the other subjects. Immunohistochemistry demonstrated that Klotho was predominantly expressed in syncytiotrophoblasts in normal term placenta.
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