Analysis of Rickets in the premature baby using a new biomarker, FGF23 and Klotho

• Project/Area Number: 22791028
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Osaka University
• Principal Investigator: ARAHORI Hitomi 大阪大学, 医学(系)研究科(研究院), 助教 (40379186)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 未熟児くる病 / 新生児 / 骨代謝 / Klotho / FGF23 / FGF23 (fibroblast growth factor)

Research Abstract

Fibroblast growth factor 23, FGF receptor, and Klotho is known to participate in homeostasis of phosphate metabolism. To determine the baseline levels of these molecule and their correlation, we measured the serum levels of soluble Klotho in fetuses and compare them with those in neonates, mothers, and adults. In cord blood, the level of Klotho was markedly higher than levels in other samples, whereas the fetal level of FGF23 was lower than levels in the other subjects. Immunohistochemistry demonstrated that Klotho was predominantly expressed in syncytiotrophoblasts in normal term placenta.

Research Products

• [Journal Article] Serum concentrations of bevacizumab (avastin) and vascular endothelial growth factor in infants with retinopathy of prematurity. (2012)
  • Author(s): Sato T, Wada K, Arahori H, Kuno N, Imoto K, Iwahashi-Shima C, Kusaka S
  • Journal Title: Am J Ophthalmol Volume: 153 Issue: 2 Pages: 327-333
  • DOI: 10.1016/j.ajo.2011.07.005
  • Peer Reviewed
• [Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood (2011)
  • Author(s): Yasuhisa Ohata, Hitomi Arahori, Noriyuki Namba, Taichi Kitaoka, Haruhiko Hirai, Kazuko Wada, Masahiro Nakayama, Toshimi Michigami, Akihiro Imura, Yo-ichi Nabeshima, Yuji Yamazaki, and Keiichi Ozono
  • Journal Title: J Clin Endocrinol Metab Volume: 96
  • Peer Reviewed
• [Journal Article] Circulating Levels of Soluble α-Klotho Are Markedly Elevated in Human Umbilical Cord Blood
  • Author(s): Yasuhisa Ohata, Hitomi Arahori, ら
  • Journal Title: The Journal of Clinical Endocrinology and Metabolism Volume: (掲載確定)
  • Peer Reviewed