| Project/Area Number |
22791046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Suzuka University of Medical Science (2011)
Institute for Developmental Research, Aichi Human Service Center (2010) |
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Principal Investigator |
FURUKAWA Ayako 鈴鹿医療科学大学, 薬学部, 助手 (10455537)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | てんかん / 酸化ストレス / 興奮毒性 / プロテオミクス / 酸化損傷タンパク質 / 海馬硬化 |
|---|
| Research Abstract |
Free radicals play a critical role in excitotoxin-induced neuronal death. However, it remains unclear which proteins are paticularly vulnerable to excitotoxin-induced oxidative damage in the epileptogenic lesion of patients with hippocampal sclerosis. To identify potential proteins specifically damaged in sclerotic hippocampus of epileptic patients, we performed proteomic analysis of carbonylated proteins in the hippocampus and temporal neocortex prepared from patients with and without hippocampal sclerosis. We found some target proteins that were particularly carbonylated in the sclerotic hippocampus.
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