analysis of Wnt target gene, Id2, in epidermal keratinocytes

• Project/Area Number: 22791050
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Tohoku University
• Principal Investigator: MEMEZAWA Ai 東北大学, 大学院・医学系研究科, 非常勤講師 (30451587)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Id2 / 表皮細胞 / Wntシグナル / 毛包

Research Abstract

Overexpression of Id2 in NHEK modulated the expression of hair follicle related genes, COL22A1, APCDD1, FGFR and KRT4. The crucial role of Wnt signaling in hair follicle development and morphogenesis has been well established. Id2 may play an important role in the regulation of hair follicle development by Wnt signaling.