| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
Keap1-Nrf2 system is known as redox homeostasis system, and also involved carcinogenesis. In this study, disruption of Keap1-Nrf2 system in skin cancers was analyzed. Seventy-two skin cancer specimens were collected and analyzed. The mutation of KEAP1 was found in only 1 specimen, and the mutation of NRF2 and LOH in KEAP1 locus were not found. Aberrant methylation of KEAP1 was found in 4 of 72 (6%) specimens; however the methylations were weak to shutoff the expression. In conclusion, disruption of Keap1-Nrf2 system in skin cancers is rare event.
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