Analysis of Keap1-Nrf2 system in skin cancers
Project/Area Number |
22791053
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | University of Tsukuba |
Principal Investigator |
|
Project Period (FY) |
2010-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 癌 / Keap1 / Nrf2 / DNAメチル化 / がん |
Research Abstract |
Keap1-Nrf2 system is known as redox homeostasis system, and also involved carcinogenesis. In this study, disruption of Keap1-Nrf2 system in skin cancers was analyzed. Seventy-two skin cancer specimens were collected and analyzed. The mutation of KEAP1 was found in only 1 specimen, and the mutation of NRF2 and LOH in KEAP1 locus were not found. Aberrant methylation of KEAP1 was found in 4 of 72 (6%) specimens; however the methylations were weak to shutoff the expression. In conclusion, disruption of Keap1-Nrf2 system in skin cancers is rare event.
|
Report
(5 results)
Research Products
(6 results)