The role of Th17 and Th22 in the development of atopic dermatitis

• Project/Area Number: 22791068
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyoto University
• Principal Investigator: HONDA Tetsuya 京都大学, 医学研究科, 助教 (40452338)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アトピー性皮膚炎 / Th17細胞 / アレルギー

Research Abstract

The role of IL-17 in the development of atopic dermatitis(AD) was investigated using mouse AD model. IL-17 deficient mice were applied to the model, and showed reduced clinical symptoms and antigen-specific IgE level in the serum. In the skin IL-17 was produced not only from Th17 cells but also gamma-delta T cells. These results suggest that IL-17 play important role in the establishment of AD.

Research Products

• [Journal Article] Enhanced murine contact hypersensitivity by depletion of endogenous regulatory T cells in the sensitization phase (2011)
  • Author(s): 本田哲也, 他
  • Journal Title: Journal of Dermatological Science Volume: 61 Issue: 2 Pages: 144-147
  • DOI: 10.1016/j.jdermsci.2010.11.001
  • NAID: 10030890224
  • Peer Reviewed
• [Journal Article] Regulatory T cells in cutaneous immune response (2011)
  • Author(s): 本田哲也, 他
  • Journal Title: Journal of Dermatological Science Volume: 63 Issue: 2 Pages: 75-82
  • DOI: 10.1016/j.jdermsci.2010.06.004
  • NAID: 10030892010
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression (2011)
  • Author(s): Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Issue: 16 Pages: 668-667
  • DOI: 10.1073/pnas.1018625108
  • Peer Reviewed
• [Journal Article] Prostanoid receptors as possible targets for anti-allergic drugs : recent advancesin prostanoids on allergy and immunology (2010)
  • Author(s): Honda T, Yoshiki Tokura, Yoshiki Miyachi, Kenji Kabashima
  • Journal Title: Current drug targets Volume: 11 Pages: 1605-23
  • URL: http://www.benthamdirect.org/pages/content.php?CDT/2010/00000011/00000012/0012J.SGM
• [Journal Article] The role of regulatory T cells in contact hypersensitivity (2010)
  • Author(s): Honda T, Yoshiki Miyachi, Kenji Kabashima
  • Journal Title: Recent Patent Inflammation and Allergy Drug Discovery Volume: 4 Pages: 85-89
  • URL: http://www.benthamdirect.org/pages/content.php?IAD/2010/00000004/00000002/0001IAD.SGM
• [Journal Article] Prostanoid receptors as possible targets for anti-allergic drugs : recent advances in prostanoids on allergy and immunology (2010)
  • Author(s): 本田哲也, 他
  • Journal Title: Current drug targets Volume: 11 Pages: 1605-1613
  • Peer Reviewed
• [Presentation] The role of regulatory T cells in the sensitization phase of mouse contact hypersensitivity (2010)
  • Author(s): Honda T, Yoshiki Miyachi, Kenji Kabashima
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-25
• [Presentation] The role of regulatory T cells in the sensitization phase of mouse contact hypersensitivity (2010)
  • Author(s): 本田哲也
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場