The role of Th17 and Th22 in the development of atopic dermatitis
Project/Area Number |
22791068
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Kyoto University |
Principal Investigator |
HONDA Tetsuya 京都大学, 医学研究科, 助教 (40452338)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | アトピー性皮膚炎 / Th17細胞 / アレルギー |
Research Abstract |
The role of IL-17 in the development of atopic dermatitis(AD) was investigated using mouse AD model. IL-17 deficient mice were applied to the model, and showed reduced clinical symptoms and antigen-specific IgE level in the serum. In the skin IL-17 was produced not only from Th17 cells but also gamma-delta T cells. These results suggest that IL-17 play important role in the establishment of AD.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression2011
Author(s)
Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Issue: 16
Pages: 668-667
DOI
Related Report
Peer Reviewed
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