Analysis and regulation of proliferative and migratory capacities of epidermal keratinocytes
Project/Area Number |
22791080
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | Ehime University |
Principal Investigator |
NANBA Daisuke 愛媛大学, 上級研究員センター, 講師 (10380255)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 皮膚炎症・再生学 / 表皮角化幹細胞 / 表皮角化細胞 / 幹細胞 / コロニー / 創傷治癒 |
Research Abstract |
We examined the association of proliferative and migratory capacities of human cultured epidermal keratinocytes and found that proliferative capacity was positively correlated with migratory capacity in keratinocytes. We also found that a kind of integrin was involved in migratory capacity of proliferative keratinocytes and that a cell behavior generated collective dynamics in the keratinocyte colony. This result leads to understanding the collective behaviors of cells with higher proliferative capacity including stem cells and tumor cells.
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Report
(3 results)
Research Products
(11 results)