Induction of chronic metal allergy and participate in intrinsic atopic dermatitis.

• Project/Area Number: 22791096
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: MORI Tomoko 産業医科大学, 医学部, 非常勤医師 (80399203)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 金属アレルギー / 内因性アトピー性皮膚炎 / ニッケル / コバルト

Research Abstract

Two types of atopic dermatitis(AD) have been proposed, the extrinsic tyoe shows high IgE levels and the intrinsic type exhibits normal IgE levels. Because I understood that the positive percentage of the metal patch test was high in intrinsic AD. I made the allergy to metal onset model mouse. However, I performed reexamination pro-experiment because individual difference was big, and the mice which were not established had much sensitization. I examined the laboratory procedure of the allergy to metal afterwards.

Research Products

• [Journal Article] Blocking CTLA-4 on lymphocytes improves the sensitivity of lymphocyte transformation test in a patient with nickel allergy (2012)
  • Author(s): Kazunari Sugita, Kenji Kabashima, Yu Sawada, Sanehito Haruyama, Manabu Yoshioka, Tomoko Mori, Miwa Kobayashi, Kouetsu Ogasawara, and Yoshiki Tokura
  • Journal Title: European Journal of Dermatology Volume: 22 Pages: 268-269
  • Peer Reviewed
• [Journal Article] Blocking of CTLA-4 on lymphocytes improves the sensitivity of lymphocyte transformation test in a patient with nickel allergy (2012)
  • Author(s): Kazunari Sugita
  • Journal Title: European Journal of Dermatology Volume: 22 Pages: 268-269
  • Peer Reviewed
• [Presentation] アトピー性皮膚炎で機能的異常はどのくらいみられるか高IgE外因性アトピー性皮膚炎(AD)と正常域IgE内因性ADの皮膚バリア能と知覚閾値の比較 (2011)
  • Author(s): 森智子
  • Organizer: アトピー性皮膚炎治療研究会第16回シンポジウム
  • Place of Presentation: 北九州国際会館(北九州)
  • Year and Date: 2011-02-05
• [Presentation] Inhibition of immediate and late-phase cutaneous reactions by blockade of D1-like dopamine receptors. (2010)
  • Author(s): Tomoko Mori, Kenji Kabashima, Jun-ichi Sakabe, Etsushi Kuroda, Shoko Fukamachi, Miwa Kobayashi, Saeko Nakajima, Motonobu Nakamura, Yoshiki Tokura
  • Organizer: 日本研究皮膚科学会第35回年次学術大会・総会
  • Place of Presentation: 和歌山(和歌山県民文化会館)
  • Year and Date: 2010-12-04
• [Presentation] Increased expression of mRNAs for IL-4, IL-17, IL-22 and IL-31 in skin lesion pf subacute and chronic form of prurigo (2010)
  • Author(s): Mori T, Park K, Nakamura M, Tokura Y
  • Organizer: The First Eastern Asia Dermatology Congress
  • Place of Presentation: Fukuoka, Japan (Hotel New Otani Hakata)
  • Year and Date: 2010-10-02
• [Presentation] Inhibition of immediate and late-phase cutaneous reactions by blockade of D1-like dopamine receptors. (2010)
  • Author(s): Mori T, Kabashima K, Kuroda E, Sakabe J, Fukamachi S, Kobayashi M, Nakajima S, Nakano K, Tanaka Y, Yamashita S, Tokura Y
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan(神戸ポートピアホテル、神戸国際展示場)
  • Year and Date: 2010-08-23
• [Presentation] D1様ドパミン受容体をブロックすることにより即時型と遅発型の皮膚反応が抑制される (2010)
  • Author(s): 森智子、椛島健治、深町晶子、黒田悦史、坂部純一、小林美和、中島沙恵子、中野和久、田中良哉、松下祥、中村元信、戸倉新樹
  • Organizer: 第75回インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州国際会館(北九州)
  • Year and Date: 2010-06-26