Research on brain pathological change and identification of predicting factors of developing schizophrenia

• Project/Area Number: 22791108
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: SUGA Motomu 東京大学, 医学部附属病院, 助教 (20553704)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 統合失調症 / こころのハイリスク状態 / MRI / 総合失調症 / アットリスク状態 / マルチモダリティ神経画像 / 神経心理

Research Abstract

We separately measured the gray matter volumes of the pars opercularis(PO) and the pars triangularis(PT) using a reliable manual-tracing volumetry in 80 participants(20 with Ultra-High-Risk, 20 with First Episode Schizophrenia, and 40 matched controls). Compared with controls, the volume of the bilateral PT, but not that of the PO, was significantly reduced in the subjects with UHR and FES. The reduced right PT volume, which showed the largest effect size among regions-of-interest in the both UHR and FES groups, correlated with the severity of the positive symptoms also in the both groups. These results suggest that localized gray matter volume reductions of the bilateral PT represent a vulnerability to schizophrenia in contrast to the PO volume, which was previously found to be reduced in patients with chronic schizophrenia. The right PT might preferentially contribute to the pathogenesis of psychotic symptoms.

Research Products

• [Journal Article] Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia (2012)
  • Author(s): Iwashiro, N., Suga, M., Takano, Y., Inoue, H., Natsubori, T., Satomura, Y., Koike, S., Yahata, N., Murakami, M., Katsura, M., Gonoi, W., Sasaki, H., Takao, H., Abe, O., Kasai, K. & Yamasue, H
  • Journal Title: Schizophr Res Volume: 137(1-3) Issue: 1-3 Pages: 124-31
  • DOI: 10.1016/j.schres.2012.02.024
  • Peer Reviewed
• [Journal Article] Effects of metabotropic glutamate receptor 3 genotype on phonetic mismatch negativity (2011)
  • Author(s): Kawakubo Y, Suga M, Tochigi M, Yumoto M, Itoh K, Sasaki T, Kano Y, Kasai K
  • Journal Title: PLoS One Volume: 6(10)
  • Peer Reviewed
• [Journal Article] Phonological fluency is uniquely impaired in Japanese-speaking schizophrenia : a confirmation study (2011)
  • Author(s): Suga Motomu, Uetsuki Miki, Takizawa Ryu, Araki Tsuyoshi, Kasai Kiyoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 672-675
  • Peer Reviewed
• [Journal Article] Reply to "Neurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults." (2011)
  • Author(s): Hidenori Yamasue, Motomu Suga, Noriaki Yahata, Hideyuki Inoue, Mamoru Tochigi, Osamu Abe, Xiaoxi Liu, Yoshiya Kawamura, Mark A Rogers, Kunio Takei, Haruyasu Yamada, Shigeki Aoki, Tsukasa Sasaki, Kiyoto Kasai
  • Journal Title: Biological Psychiatry
  • Peer Reviewed
• [Journal Article] Criterion and Construct Validity of the CogState Schizophrenia Battery in Japanese Patients with Schizophrenia (2011)
  • Author(s): Taisuke Yoshida, Motomu Suga, Kunimasa Arima, Yasuko Muranaka, Tsunehiko Tanaka, Satoshi Eguchi, Crystal Lin, Sumiko Yoshida, Masanori Ishikawa, Yuko Higuchi, Tomonori Seo, Yoshinori Ueoka, Masahito Tomotake, Yasuhiro Kaneda, David Darby, Paul Maruff, Masaomi Iyo, Kiyoto Kasai, Teruhiko Higuchi, Tomiki Sumiyoshi, Tetsuro Ohmori, Kiyohisa Takahashi, Kenji Hashimoto
  • Journal Title: PLoS ONE Volume: 6(5)
  • Peer Reviewed
• [Journal Article] Impaired ability to organize information in individuals with autism spectrum disorders and their siblings, Neuroscience Research (2011)
  • Author(s): Chika Sumiyoshi, Yuki Kawakubo, Motomu Suga, Tomiki Sumiyoshi, Kiyoto Kasai
  • Journal Title: Neurosci Res Volume: 69(3) Pages: 252-7
  • Peer Reviewed
• [Journal Article] Phonological fluency is uniquely impaired in Japanese-speaking schizophrenia patients: confirmation study. (2011)
  • Author(s): Suga M, Uetsuki M, Takizawa R, Araki T, Kasai K.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65 Issue: 7 Pages: 672-675
  • DOI: 10.1111/j.1440-1819.2011.02281.x
  • Peer Reviewed
• [Journal Article] A case of adult onset type II citrullinemia with comorbid epilepsy even after liver transplant Epilepsia (2010)
  • Author(s): Yosuke Eriguchi, Hidenori Yamasue, Nagafumi Doi, Takuji Nishida, Osamu Abe, Haruyasu Yamada, Shigeki Aoki, Motomu Suga, Hideyuki Inoue, Hiroi Nonaka, Takayuki Obata, Hiroo Ikehira, Keiko Kobayashi, and Kiyoto Kasai
  • Volume: 51(12)
  • Pages: 2484-7
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders (2010)
  • Author(s): Syudo Yamasaki, Hidenori Yamasue, Osamu Abe, Motomu Suga, Haruyasu Yamada, Hideyuki Inoue, Hitoshi Kuwabara, Yuki Kawakubo, Noriaki Yahata, Shigeki Aoki, Yukiko Kano, Nobumasa Kato, Kiyoto Kasai
  • Journal Title: Biol Psychiatry Volume: 68(12) Pages: 1141-7
  • Peer Reviewed
• [Journal Article] Association between the oxytocin receptor gene(OXTR) and amygdalar volume in healthy adults (2010)
  • Author(s): Hideyuki Inoue, Hidenori Yamasue, Mamoru Tochigi, Osamu Abe, Xiaoxi Liu, Yoshiya Kawamura, Kunio Takei, Motomu Suga, Haruyasu Yamada, Mark A Rogers, Shigeki Aoki, Tsukasa Sasaki, Kiyoto Kasai
  • Journal Title: Biol Psychiatry Volume: 68(11) Pages: 1066-72
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia (2010)
  • Author(s): Suga M, Yamasue H, Abe O, Yamasaki S, Yamada H, Inoue H, Takei K, Aoki S, Kasai K
  • Journal Title: Eur Arch Psychiatry Clin Neurosci Volume: 260(6) Pages: 465-473
  • Peer Reviewed
• [Journal Article] Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging (2010)
  • Author(s): Abe O, Yamasue H, Yamada H, Masutani Y, Kabasawa H, Sasaki H, Takei K, Suga M, Kasai K, Aoki S, Ohtomo K
  • Journal Title: NMR Biomed Volume: 23(5) Pages: 446-58
  • Peer Reviewed
• [Journal Article] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Takei K, Suga M, Abe O, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
  • Journal Title: Brain Res Volume: 1331 Pages: 51-7
  • Peer Reviewed
• [Journal Article] Functional(GT) n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit(GRIN2A) gene affect hippocampal and amygdala volumesFunctional(GT) n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit(GRIN2A) gene affect hippocampal and amygdala volumes (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Suga M, Iwayama Y, Abe O, Yamada H, Rogers MA, Aoki S, Kato T, Sasaki T, Yoshikawa T, Kasai K
  • Journal Title: Genes Brain Behav Volume: 9(3) Pages: 269-75
  • Peer Reviewed
• [Journal Article] Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression (2010)
  • Author(s): Abe O, Yamasue H, Kasai K, Yamada H, Aoki S, Inoue H, Takei K, Suga M, Matsuo K, Kato T, Masutani Y, Ohtomo K
  • Journal Title: Psychiatry Res Neuroimaging Volume: 181 Pages: 64-70
  • NAID: 10025695966
  • Peer Reviewed
• [Journal Article] Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia. Norichika Iwashiro
  • Author(s): Motomu Suga, Yosuke Takano, Hideyuki Inoue, Tatsunobu Natsubori, Yoshihiro Satomura, Shinsuke Koike, Noriaki Yahata, Mizuho Murakami, Masaki Katsura, Wataru Gonoi, Hiroki Sasaki, Hidemasa Takao, Osamu Abe, Kiyoto Kasai, and Hidenori Yamasue
  • Journal Title: Schizophrenia Research, in press
  • Peer Reviewed
• [Journal Article] 脳梁の解剖と機能
  • Author(s): 岩白訓周、管心、西田拓司、笠井清登
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 1177-1180
• [Presentation] 統合失調症認知評価尺度を用いた精神病発症前後における予後予測因子の検討 (2012)
  • Author(s): 管心、小池進介、高野洋輔、里村嘉弘、岩白訓周、多田真理子、夏堀龍暢、永井達哉、江口聡、下條千恵、山崎修道、荒木剛、笠井清登
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-17
• [Presentation] 精神科デイケアにおけるアウトリーチ支援を生かした就学支援の取り組み～東大デイホスピタルの実践から～ (2012)
  • Author(s): 石橋綾,藤枝由美子,清水希実子,山崎修道,江口聡,飯田恵美,林里織、柴田貴美子,管心,古川俊一
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-17
• [Presentation] 双生児研究法による近赤外線スペクトロスコピーの前頭側頭部血流変化における遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔、管心ら
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-17
• [Presentation] 初回エピソード統合失調症における語流暢性課題を用いた近赤外線スペクトロスコピィによる血流変化の縦断的変化と社会機能の予測 (2012)
  • Author(s): 小池進介、管心ら
  • Organizer: 名古屋
  • Place of Presentation: 第7回日本統合失調症学会
  • Year and Date: 2012-03-17
• [Presentation] 初発統合失調症群と精神病状態の高リスク群に共通して認められる下前頭回における三角部に限局した灰白質体積減少とその陽性症状発現との関連 (2012)
  • Author(s): 岩白訓周、管心ら
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-17
• [Presentation] 初回エピソード統合失調症における語流暢性課題を用いた近赤外線スペクトロスコピィによる血流変化の縦断的変化と社会機能の予測 (2012)
  • Author(s): 小池進介, ら
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-16
• [Presentation] 精神病発症超危険群、初回エピソード精神病群に対する認知機能の縦断的検討 (2011)
  • Author(s): 江口聡、管心、小池進介、高野洋輔、里村嘉弘、岩白訓周、山崎修道、下條千恵、荒木剛、笠井清登
  • Organizer: 第15回日本精神保健・予防学会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-03
• [Presentation] 精神科デイケアにおけるアウトリーチによる就労就学支援の試み～東大デイホスピタルの実践から～ (2011)
  • Author(s): 石橋綾、藤枝由美子、清水希実子、山崎修道、柴田貴美子、村上安立、飯田美恵、管心、古川俊一
  • Organizer: 第19回日本精神障害者リハビリテーション学会
  • Place of Presentation: 京都
  • Year and Date: 2011-11-16
• [Presentation] 統合失調症認知評価尺度を用いた精神病発症前後の検討 (2011)
  • Author(s): 管心、小池進介、高野洋輔、里村嘉弘、岩白訓周、江口聡、下條千恵、山崎修道、荒木剛、笠井清登
  • Organizer: 第11回精神疾患と認知機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] 統合失調症認知評価尺度を用いた精神病発症前後の検討 (2011)
  • Author(s): 管心, ら
  • Organizer: 第11回精神疾患と認知機能研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-05
• [Presentation] 統合失調症認知評価尺度-日本語版(SCoRS-J)による認知機能評価に対する臨床病期の影響(第2報) (2011)
  • Author(s): 瀬尾友徳、管心、樋口悠子、山崎修道、植月美希、江口聡、松岡理、宮西知広、鈴木道雄、兼田康宏、笠井清登、住吉太幹
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-18
• [Presentation] 日本精神保健 (2010)
  • Author(s): 統合失調症認知機能簡易評価尺度-日本語版(BACS-J)による認知機能評価への臨床病期の影響、瀬尾友徳、管心ら
  • Organizer: 予防学会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-12
• [Presentation] 統合失調症認知機能評価尺度を用いた精神病発症前後の検討 (2010)
  • Author(s): 管心
  • Organizer: 日本精神保健・予防学会
  • Place of Presentation: 灘尾ホール 東京
  • Year and Date: 2010-12-12
• [Presentation] 東京大学医学部附属病院「こころのリスク外来」およびIN-STEP研究の概況 (2010)
  • Author(s): 小池進介
  • Organizer: 日本精神保健・予防学会
  • Place of Presentation: 灘尾ホール 東京
  • Year and Date: 2010-12-11
• [Presentation] 統合失調症認知機能簡易評価尺度-日本語版(BACS-J)による認知機能評価への臨床病期の影響 (2010)
  • Author(s): 瀬尾友徳
  • Organizer: 日本精神保健・予防学会
  • Place of Presentation: 灘尾ホール 東京
  • Year and Date: 2010-12-11
• [Presentation] ARMS群と初発統合失調症群における下前頭回の灰白質体積減少 (2010)
  • Author(s): 岩白訓周
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉
• [Book] 精神疾患診断のための脳形態・機能検査法 (2012)
  • Author(s): 武井雄一、管心、栗田澄江、笠井清登、福田正人、三國雅彦
  • Total Pages: 230
  • Publisher: 新興医学出版社
• [Book] 精神疾患診断のための脳形態・機能検査法,脳磁図(MEG)の精神疾患診断への応用 (2012)
  • Author(s): 武井雄一、管心、栗田澄江、笠井清登、福田正人、三國雅彦
  • Publisher: 新興医学出版社(印刷中)
• [Remarks]
  • URL: http://plaza.umin.ac.jp/arms-ut/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/arms-ut/
• [Remarks]
  • URL: http://olaza_umin.ac.jp/erms-ut/