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Angiogenesis, neurogenesis and anti-depressive effect of CD34 positive stem cell transplantation in rat brain.

Research Project

Project/Area Number 22791119
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KAMENO Yosuke  浜松医科大学, 医学部, リサーチアシスタント (40537255)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords精神生理学 / 血管・神経新生 / うつ病 / 脳内血流 / CD34
Research Abstract

In recent studies, recovery of cerebral blood flow emerged as a novel therapeutic strategy for depression. To establish animal model for the therapy method research, I tried to transplant CD34 positive hematopoietic stem cell into rat brain through the internal carotid artery and succeeded to confirm its proliferation in the rat brain capillaries after transfusion in this project. However, I regretted to discontinue the project because the survival rate of rat was less than 60% within 1 week after transfusion.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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