| Project/Area Number |
22791138
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
KIUCHI Kuniaki 奈良県立医科大学, 医学部, 助教 (20398449)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 拡散テンソルトラクトグラフィー / アルツハイマー病 / 主観的認知障害 / 拡散テンソル画像 / Subjective Cognitive Impairment / Dementia / diffusion tensor imaging / Alzheimer's disease / 認知症 / アルツハイマー型認知症 / 拡散テンソル / SCI / 物忘れ / トラクトグラフィー |
|---|
| Research Abstract |
Amnestic mild cognitive impairment(aMCI) is considered to be a transitional stage in Alzheimer's disease(AD). Several studies using diffusion tensor imaging(DTI) showed abnormalities of the white matter in aMCI patients. Subjective cognitive impairment(SCI) is thought to be a preclinical stage in the course of AD that may precede aMCI. In this DTI study, we investigated on SCI subjects(n=22) by comparing age matched early AD(n=27), aMCI(n=28) and normal control(NC)(n=28). SCI subjects had lower FA region in the posterior cingulum than NC. This finding may represent early subtle change in the course of dementia.
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