Research for efficacy of radiation-induced auto-immune response in radiation therapy
| Project/Area Number |
22791169
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba (2011)
Gunma University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腫瘍免疫 / 放射線治療 / サイトカイン / 抗腫瘍免疫 / 抗体療法 |
|---|
| Research Abstract |
TCD50 of the tumors was estimated to be 40 Gy, and all cytokine levels in the plasma were up-regulated with radiation-dose-dependency. After TCD50 irradiation to the 10 tested tumors, 5 were controlled (C-group) and 5 developed progression within 14 days (R-group). The levels of GM-CSF, IFN-γ, and TNF-α in the supernatants of 48 hr-cultivated spleen cells obtained 28 days after irradiation in the C-group (48 hr) were 37.8 ± 10.1 pg/ml, 5.4 ± 6.9 pg/ml, and 21.2 ± 6.6 pg/ml, respectively, but those in the R-group were 23.7 ± 13.0 pg/ml, 0.6 ± 0.6 pg/ml, and 13.1 ± 5.6 pg/ml, respectively. A significant difference in IFN-γ between the two groups was observed. Similarly, plasma IFN-γ level 28 days after 40 Gy-irradiation in the C-group (12.0 ± 18.7 pg/ml) was higher than that in the R-group (0.9 ± 0.7 pg/ml), but the difference did not reach the significant level.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Dose-volume histogram parameters and clinical factors associated with pleural effusion after chemoradiotherapy in esophageal cancer patients2011
Author(s)
Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Nonaka T, Ishikawa H, Katoh H, Takahashi T, Nakano T
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 80(4)
Pages: 1002-7
Related Report
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[Journal Article] Genetic variants ofNPAT-ATM and AURKA are associated withan early adverse reaction in thegastrointestinal tract of patientswith cervical cancer treated withpelvic radiation therapy.2011
Author(s)
Ishikawa A, Suga T, Shoji Y, Kato S,Ohno T, Ishikawa H, Yoshinaga S, OharaK, Ariga H, Nomura K, Shibamoto Y,Ishikawa K, Moritake T, Michikawa Y,Iwakawa M, Imai T.
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Journal Title
Int JRadiat Oncol Biol Phys.
Volume: 81
Issue: 4
Pages: 1144-52
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of Hypoxia-inducible Factor 1.ALPHA. Predicts Clinical Outcome after Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer2011
Author(s)
Shioya M, Takahashi T, Sakurai H,Ebara T, Suzuki Y, Saitoh J, Ohno T,Asao T, Kuwano H, Nakano T.
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Journal Title
Journal of Radiation Research
Volume: 52
Issue: 6
Pages: 821-827
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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