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Research for efficacy of radiation-induced auto-immune response in radiation therapy

Research Project

Project/Area Number 22791169
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Tsukuba (2011)
Gunma University (2010)

Principal Investigator

ISHIKAWA Hitoshi  筑波大学, 医学医療系, 准教授 (70344918)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords腫瘍免疫 / 放射線治療 / サイトカイン / 抗腫瘍免疫 / 抗体療法
Research Abstract

TCD50 of the tumors was estimated to be 40 Gy, and all cytokine levels in the plasma were up-regulated with radiation-dose-dependency. After TCD50 irradiation to the 10 tested tumors, 5 were controlled (C-group) and 5 developed progression within 14 days (R-group). The levels of GM-CSF, IFN-γ, and TNF-α in the supernatants of 48 hr-cultivated spleen cells obtained 28 days after irradiation in the C-group (48 hr) were 37.8 ± 10.1 pg/ml, 5.4 ± 6.9 pg/ml, and 21.2 ± 6.6 pg/ml, respectively, but those in the R-group were 23.7 ± 13.0 pg/ml, 0.6 ± 0.6 pg/ml, and 13.1 ± 5.6 pg/ml, respectively. A significant difference in IFN-γ between the two groups was observed. Similarly, plasma IFN-γ level 28 days after 40 Gy-irradiation in the C-group (12.0 ± 18.7 pg/ml) was higher than that in the R-group (0.9 ± 0.7 pg/ml), but the difference did not reach the significant level.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Remarks (2 results)

  • [Journal Article] Rectal bleeding after high-dose-rate brachytherapy combined with hypofractionated external-beam radiotherapy forlocalized prostate cancer : the relationship between dose-volume histogram parameters and the occurrencerate2012

    • Author(s)
      Okamoto M, Ishikawa H, Ebara T, et al
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82(2) Issue: 2 Pages: e211-e217

    • DOI

      10.1016/j.ijrobp.2011.03.041

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparison of efficacy and safety of low-dose-rate vs. high-dose-rate intraluminal brachytherapy boost in patients with superficial esophageal cancer.2012

    • Author(s)
      Tamaki T, Ishikawa H, Takahashi T, et al
    • Journal Title

      Brachytherapy

      Volume: 11 Issue: 2 Pages: 130-6

    • DOI

      10.1016/j.brachy.2011.05.008

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon-ion radiation for prostate cancer2012

    • Author(s)
      Ishikawa H, Tsuji H, Kamada T, Akakura K, Suzuki H, et al
    • Journal Title

      Int J Urol

      Volume: 19 Issue: 4 Pages: 296-305

    • DOI

      10.1111/j.1442-2042.2012.02961.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of chemoradiotherapy with radiotherapy alone in patients with esophageal adenocarcinoma2011

    • Author(s)
      Shirai K, Tamaki Y, Kitamoto Y, Takahashi T, Ishikawa H, Nonaka T, Murata K, Satoh Y, Higuchi K, Nakano T.
    • Journal Title

      J Radiat Res (Tokyo)

      Volume: 52(3) Pages: 264-9

    • NAID

      10028111008

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dose-volume histogram parameters and clinical factors associated with pleural effusion after chemoradiotherapy in esophageal cancer patients2011

    • Author(s)
      Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Nonaka T, Ishikawa H, Katoh H, Takahashi T, Nakano T
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 80(4) Pages: 1002-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic variants ofNPAT-ATM and AURKA are associated withan early adverse reaction in thegastrointestinal tract of patientswith cervical cancer treated withpelvic radiation therapy.2011

    • Author(s)
      Ishikawa A, Suga T, Shoji Y, Kato S,Ohno T, Ishikawa H, Yoshinaga S, OharaK, Ariga H, Nomura K, Shibamoto Y,Ishikawa K, Moritake T, Michikawa Y,Iwakawa M, Imai T.
    • Journal Title

      Int JRadiat Oncol Biol Phys.

      Volume: 81 Issue: 4 Pages: 1144-52

    • DOI

      10.1016/j.ijrobp.2010.09.012

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Hypoxia-inducible Factor 1.ALPHA. Predicts Clinical Outcome after Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer2011

    • Author(s)
      Shioya M, Takahashi T, Sakurai H,Ebara T, Suzuki Y, Saitoh J, Ohno T,Asao T, Kuwano H, Nakano T.
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Issue: 6 Pages: 821-827

    • DOI

      10.1269/jrr.11117

    • NAID

      10029653265

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 8-year survivor of unresectable intrapelvic desmoplastic small round cell tumor treated with concurrent chemoradiotherapy2011

    • Author(s)
      Saitoh J, Ishikawa H, Ebara T. et al
    • Journal Title

      Iran. J. Radiat. Res

      Volume: 9(3) Pages: 201-205

    • Related Report
      2011 Final Research Report
  • [Journal Article] Protective Effect of Urinary Trypsin Inhibitor on the Development of Radiation-Induced Lung Fibrosis in Mice2010

    • Author(s)
      Katoh H, Ishikawa H, Hasegawa M,Yoshida Y, Suzuki Y, Ohno T, TakahashiT, Nakano T.
    • Journal Title

      Journal of Radiation Research

      Volume: 51 Issue: 3 Pages: 325-332

    • DOI

      10.1269/jrr.09108

    • NAID

      10026471232

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon ion radiotherapy for treatment of prostate cancer and subsequent outcomes after biochemical failure2010

    • Author(s)
      Shimazaki J, Tsuji H, Ishikawa H, Okada T, Akakura K, Suzuki H, M. Harada M, Tsujii H
    • Journal Title

      Anticancer Res

      Volume: 30(12) Pages: 5105-11

    • Related Report
      2011 Final Research Report
  • [Journal Article] Current Advancement in Radiation Therapy for Uterine Cervical Cancer2010

    • Author(s)
      Nakano T, Ohno T, Ishikawa H, SuzukiY, Takahashi T.
    • Journal Title

      Journal of Radiation Research

      Volume: 51 Issue: 1 Pages: 1-8

    • DOI

      10.1269/jrr.09132

    • NAID

      10025913850

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The benefit of small bowel and pelvic bone sparing in excluding common iliac lymph node region from conventional radiation fields in patients with uterine cervical cancer2010

    • Author(s)
      Oike T
    • Journal Title

      J Rad Res

      Volume: 51(6) Pages: 715-721

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon radiotherapy for treatment of prostate cancer and subsequent outcomes after biochemical failure2010

    • Author(s)
      Shimazaki J
    • Journal Title

      Anticancer Res

      Volume: 30(12) Pages: 5105-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-Volume Histogram Parameters and Clinical Factors Associated with Pleural Effusion After Chemoradiotherapy in Esophageal Cancer Patients.

    • Author(s)
      Shirai K
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 前立腺癌放射線治療の実践と治療成績(教育講演)2012

    • Author(s)
      石川仁
    • Organizer
      茨城県泌尿器科地方会
    • Place of Presentation
      つくば
    • Year and Date
      2012-03-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Radiation therapy principles for prostate cancer2012

    • Author(s)
      Ishikawa H
    • Organizer
      (Educational lecture) IAEA-RCA training course of radiation therapy
    • Place of Presentation
      Maebashi
    • Related Report
      2011 Final Research Report
  • [Presentation] High-dose-rate intraluminal brachytherapy combined with external beam radiation therapy for medically inoperable patients with stage I thoracic esophageal cancer2011

    • Author(s)
      Ishikawa H, et al.
    • Organizer
      The 53^<rd> Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      Miami, USA
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] I期胸部食道扁平上皮癌に対する高線量率腔内照射併用放射線治療成績2011

    • Author(s)
      石川仁, 野田真永, 今枝真澄
    • Organizer
      第65回日本食道学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] High-dose-rate intraluminal brachytherapy combined with external beam radiation therapy for medically inoperable patients with Stage I thoracic esophageal cancer2011

    • Author(s)
      Ishikawa H, Katoh H, Tamaki T, et al
    • Organizer
      The 53^<rd> Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      Miami, USA.
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌に対する外部照射併用高線量率組織内照射の治療成績2011

    • Author(s)
      石川仁, 加藤弘之, 神沼拓也
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] I期胸部食道扁平上皮癌に対する腔内照射併用放射線治療成積2011

    • Author(s)
      石川仁, 野田真永, 今枝真澄
    • Organizer
      日本放射線腫瘍学会小線源部会第13回研究会
    • Place of Presentation
      那覇
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌に対する炭素イオン線治療の初期経験2010

    • Author(s)
      石川仁, 加藤弘之, 大野達也ら
    • Organizer
      第7回日本粒子線治療臨床研究会
    • Place of Presentation
      福井
    • Year and Date
      2010-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] High-dose rate brachytherapy combined with hypofractionated external beam radiotherapy for locally advanced prostate cancer2010

    • Author(s)
      Ishikawa H, Katoh H, Ebara T, et al
    • Organizer
      The 52nd American American Society for Radiation Oncology Annual Meeting
    • Place of Presentation
      San Diego, USA.
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線治療効果予測に関する基礎的研究2010

    • Author(s)
      石川仁
    • Organizer
      第57回北関東医学会総会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report
  • [Presentation] 中・高リスク前立腺癌に対する高線量率組織内照射の治療成績2010

    • Author(s)
      石川仁, 加藤弘之, 江原威ら
    • Organizer
      日本放射線腫瘍学会第23回学術大会
    • Place of Presentation
      浦安
    • Related Report
      2011 Final Research Report
  • [Presentation] I期食道癌に対する高線量率腔内照射と低線量率腔内照射の治療成績比較2010

    • Author(s)
      石川仁, 高橋健夫, 玉木義雄ら
    • Organizer
      第69回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] HDR-brachytherapy combined with hypofractionated external beam radiation therapy fpr locally advanced prostate cancer.2010

    • Author(s)
      Ishjkawa H
    • Organizer
      The 52^<nd> American American Society for Radiation Oncology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pmrc.tsukuba.ac.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www3.pmrc.tsukuba.ac.jp/

    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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