Studies about the combination of radiotherapy, hyperthermia, and a radiosensitizer

• Project/Area Number: 22791208
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: TAKAGI Masaru 札幌医科大学, 医学部, 特任助教 (10404716)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 放射線治療生物学 / 放射線治療 / 抗癌剤 / 増感剤 / 温熱

Research Abstract

Gimeracil is a component of TS-1, an anti-cancer drug. Gimeracil enhanced cell-killing effects of camptothecin(CPT), 5-Fluorouracil(5-FU), and hydroxyurea. Combination of Gimeracil and CPT or 5-FU sensitized radiation more effectively than each modality alone. Gimeracil also enhanced heat sensitivity at 42℃or more. Combination of Gimeracil and heat sensitized radiation more than each modality alone did.

Research Products

• [Journal Article] The combination of hyperthermia or chemotherapy with Gimeracil for effective radiosensitization (2012)
  • Author(s): Takagi M, Sakata K, Someya M, Matsumoto Y, Tauchi H, Hareyama M, Fukushima M
  • Journal Title: Strahlenther Onkol Volume: 188 Pages: 255-261
  • Peer Reviewed
• [Journal Article] Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination (2011)
  • Author(s): Sakata K, Someya M, Matsumoto Y, Tauchi H, Kai M, Toyota M, Takagi M, Hareyama M, Fukushima M
  • Journal Title: Cancer Sci Volume: 102(9) Pages: 1712-1716
  • NAID: 10030243264
  • Peer Reviewed
• [Journal Article] Gimeracil sensitizes cell to radiation via inhibition of homologous recombination (2010)
  • Author(s): Takagi M, Sakata K, Someya M, Tauchi H, Iijima K, Matsumoto Y, Torigoe T, Takahashi A, Hareyama M, Fukushima M
  • Journal Title: Radiother Oncol Volume: 96 Pages: 259-266
  • Peer Reviewed
• [Presentation] DNA2重鎖切断修復と放射線増感 (2011)
  • Author(s): 坂田耕一
  • Organizer: 第23回日本放射線腫瘍学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-09