Development of MRI probe for early diagnosis of pancreatic cancer
| Project/Area Number |
22791237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 膵がん / RGDペプチド / MRI / 分子イメージング / 早期診断 |
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| Research Abstract |
Pancreatic cancer expresses αvβ_3インテグリン. In this study, we synthesized RGD targeting liposomes which loaded Fe-deferoxamine for magnetic resonance imaging(MRI). In MR imaging study using Panc-1 bearing mice, the significant contrast enhancement was not obtained in the visual evaluation. However, RGD targeting liposome increased tumor to muscle signal ratio on T1 weighted images.
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Report
(3 results)
Research Products
(10 results)
