Ischemia reperfusion injury induced abrogation of lung transplant acceptance

Research Project

Project/Area Number	22791251
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Okayama University
Principal Investigator	SUGIMOTO Seiichiro 岡山大学, 岡山大学病院, 助教 (40570148)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	肺移植 / 虚血再灌流障害 / 急性拒絶反応 / 免疫寛容 / 虚血再還流障害
Research Abstract	Lung transplantation has become the treatment of end-stage lung disease. However, outcomes after lung transplantation remain worse than those after transplantation of other solid organs. Ischemia reperfusion injury is considered to be linked to the limitation to long term survival after lung transplantation. We examined the mechanism that ischemia reperfusion injury induces the abrogation of lung transplant acceptance.

Report

(3 results)