Ischemia reperfusion injury induced abrogation of lung transplant acceptance

• Project/Area Number: 22791251
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Okayama University
• Principal Investigator: SUGIMOTO Seiichiro 岡山大学, 岡山大学病院, 助教 (40570148)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 肺移植 / 虚血再灌流障害 / 急性拒絶反応 / 免疫寛容 / 虚血再還流障害

Research Abstract

Lung transplantation has become the treatment of end-stage lung disease. However, outcomes after lung transplantation remain worse than those after transplantation of other solid organs. Ischemia reperfusion injury is considered to be linked to the limitation to long term survival after lung transplantation. We examined the mechanism that ischemia reperfusion injury induces the abrogation of lung transplant acceptance.

Research Products

• [Presentation] 骨髄細胞IκBキナーゼβの欠損による肺移植後免疫寛容の導入阻害 (2010)
  • Author(s): 杉本誠一郎, Huang HJ, 岡崎幹生, 脇直久, 三好健太郎, 大谷真二, 原田昌明, 山根正修, 大藤剛宏, Patterson GA, Kreisel D, Gelman AE, 三好新一郎
  • Organizer: 第63回日本胸部外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-10-25
• [Presentation] 緊急顆粒球形成による移植肺の生着阻害 (2010)
  • Author(s): 杉本誠一郎, 岡崎幹生, 脇直久, 三好健太郎, 大谷真二, 原田昌明, 山根正修, 大藤剛宏, Patterson GA, Kreisel D, Gelman AE, 三好新一郎
  • Organizer: 第46回日本移植学会総会
  • Place of Presentation: 京都みやこメッセ
  • Year and Date: 2010-10-22