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Role of the FOXF2 gene in the cancer activated fibroblasts that support proliferation of colon cancer cells

Research Project

Project/Area Number 22791272
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SULTANA Nishat  浜松医科大学, 医学部, リサーチアシスタント (80529503)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords癌付随線維芽細胞 / 大腸癌 / Foxf2遺伝子 / 増殖 / 腫瘍微小環境 / 癌細胞増殖 / FOXF2 / 上皮-間葉相互作用 / 転移能 / Wnt5a / Wint
Research Abstract

When colon cancer cells HT29 were transplanted with intestinal embryonic fibroblasts(IEFs) from the Foxf2-/-and wild-type mice, the efficiency and tumor size were highest in cotranslantation with the wild-type IEFs, higher in that with the Foxf2-/-IEFs compared to that without fibroblasts. I isolated RNas from IEFs from the Foxf2-/-and wild-type mice and applied to DNA microarray analysis. I found 23 genes were significantly higher in the wild-type compared to the Foxf2-/-mice. I chose one gene named Wnt5a and demonstrated that the Wnt5a-expressing fibroblasts increased the efficiency and tumor size of HT29 cell transplantation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an up-regulation of c-Myc target genes2012

    • Author(s)
      Wang B, Hikosaka K, Sultana N, Sharkar MTK, Noritake H, Kimura W, Wu Y-X, Kobayashi Y, Uezato T, Miura N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Pages: 601-606

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an up-regulation of c-Myc target genes2012

    • Author(s)
      Wang B, et al
    • Journal Title

      Biochemica Biophysica Res Commun

      Volume: 417 Issue: 1 Pages: 601-606

    • DOI

      10.1016/j.bbrc.2011.12.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry2011

    • Author(s)
      Hikosaka K, Noritake H, Kimura W, Sultana N, Skarkar MTK, Tagawa Y, Uezato T, Kobayashi Y, Wakita T, Miura N
    • Journal Title

      Biomed Res

      Volume: 32 Pages: 143-150

    • NAID

      130004470774

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskletal system development2011

    • Author(s)
      Kimura W, Machii M, Xue X-D, Sultana N, Hikosaka K, Sharkar MTK, Uezato T, Matsuda M, Koseki H, Miura N
    • Journal Title

      Genesis

      Volume: 49 Pages: 2-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irxl1 mutant mice show reduced tendon differentiation and no pattening defects in musculoskletal system development.2011

    • Author(s)
      Kimura, W., et al.
    • Journal Title

      Genesis

      Volume: 49 Pages: 2-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10(lacZ) allele.2010

    • Author(s)
      Xue, X-D., et al.
    • Journal Title

      Genesis

      Volume: 48 Pages: 295-302

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mouse forkhead gene Foxp2 modulates expression of the lung genes.2010

    • Author(s)
      Yang, Z., et al.
    • Journal Title

      Life Sciences

      Volume: 87 Pages: 17-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Isl1-specific knockout of Sonic hedgehog results in craniofacial and cardiac defects2011

    • Author(s)
      Sharkar M, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Irx3 determines expression of fast and slow connexins in the ventricular conduction system of the mouse heart2011

    • Author(s)
      Sultana N, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Irx3遺伝子はマウス心臓心室刺激伝導系のコネキシンの発現を調節する2011

    • Author(s)
      木村航, 他
    • Organizer
      第10回心臓血管発生研究会
    • Place of Presentation
      郡山
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation of the Tbx1-AmCyan transgenic mice and its application2011

    • Author(s)
      Kimura W, et al.
    • Organizer
      Machanism of cardiac Growth, Death and Regeneration
    • Place of Presentation
      Keystone CO.
    • Related Report
      2011 Final Research Report
  • [Presentation] Irxl1 is required for tendon differentiation during mouse musculoskeletal system development2011

    • Author(s)
      Kimura W, et al.
    • Organizer
      Joint Meeting of the German and Japanese Societies of Developmental Biology
    • Place of Presentation
      Dresden Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation of the Tbxl-AmCyan transgenic mice and its application.2011

    • Author(s)
      Miura, N., et al.
    • Organizer
      Keystone Symposia on "Machanism of cardiac Growth, Death and Regeneration"
    • Place of Presentation
      Keystone CO, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Creation of a Tbx1-AmCyan1 transgenic mice and its application to characterize the Tbx1-expressing cells2010

    • Author(s)
      木村航, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1a/bio2/index-j.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2021-04-07  

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