Explication of the mechanism of chemoresistance using video mass scope

• Project/Area Number: 22791282
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: TSUTANI Yasuhiro 広島大学, 原爆放射腺医科学研究所, 助教 (10534985)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 抗癌剤耐性株

Research Abstract

We performed microarray analyses for chemoresistant cell lines such as gastric cancer and esophageal cancer. We found chemoresistance related genes for 5-FU, oxaliplatin, and CPT-11, respectively. Especially, in oxaliplatin reistant cell lines, we discovered common up regulated genes such as AGR2, MUC4, LGALS7, GJB6, and KDM5D, and down regulated genes such as FLRT2, SLC25A27, ANKRD20A1, FRG1, and SAMD4A.

Research Products

• [Journal Article] Upregulation of notch2and six1 is associated with progression of early-stage lung adenocarcinoma and a moreaggressive phenotype at advanced stages (2012)
  • Author(s): Mimae T, Okada M, Hagiyama M, Miyata M, Tsutani Y, et al
  • Journal Title: Clinical Cancer Research Volume: 15 Pages: 945-55
  • Peer Reviewed
• [Journal Article] Notch2 and Six1 are up-regulated during progression of early-stage lung adenocarcinoma and define its unfavorable subset at advanced stages. (2012)
  • Author(s): Mimae T, Murakami Y, Ito A et al.
  • Journal Title: Clinical Cancer Research Volume: 18 Issue: 4 Pages: 945-948
  • DOI: 10.1158/1078-0432.ccr-11-1946
  • Peer Reviewed
• [Presentation] メタボローム解析によるヒト胃癌細胞株の抗がん薬に対する細胞内分子応答および耐性因子の探索 (2012)
  • Author(s): 笹田伸介
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千千葉
• [Presentation] 質量分析法を用いたヒト胃癌細胞株における抗がん薬に対する細胞内分子応答の解析 (2011)
  • Author(s): 笹田伸介
  • Organizer: 第83回日本胃癌学会総会
  • Place of Presentation: 青森
  • Year and Date: 2011-03-04
• [Presentation] 質量分析法を用いたヒト胃癌細胞株における抗がん薬に対する細胞内分子応答の解析 (2011)
  • Author(s): 笹田伸介
  • Organizer: 第83回日本胃癌学会総会
  • Place of Presentation: 青森県
  • Year and Date: 2011-03-04