Induction of autophagic cell death via microRNA-mediated gene regulatory network
| Project/Area Number |
22791310
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / マイクロRNA / アデノウイルス / テロメラーゼ / オートファジー |
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| Research Abstract |
Tumor-specific replication-competent oncolytic adenovirus is a promising antitumor agent. However, the mechanism on the virus-mediated cell death remains unclear. Here we show that telomerase-specific replication-competent oncolytic adenovirus Telomelysin induces autophagic cell death through microRNA-mediated gene regulatory network.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells2013
Author(s)
Hasei J, Sasaki T, Tazawa H, Osaki S, Yamakawa Y, Kunisada T, Yoshida A, Hashimoto Y, Onishi T, Uno F, Kagawa S, Urata Y, Ozaki T, Fujiwara T
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Journal Title
Mol Cancer Ther
Volume: 12: 314-325
NAID
Related Report
Peer Reviewed
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[Journal Article] A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus2013
Author(s)
Sasaki T, Tazawa H, Hasei J, Osaki S, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Kagawa S, Uno F, Urata Y, Ozaki T, Fujiwara T
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Journal Title
Gene Ther
Volume: 20: 112-118
Related Report
Peer Reviewed
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[Journal Article] Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells2012
Author(s)
Yoshida R, Tazawa H, Hashimoto Y, Yano S, Onishi T, Sasaki T, Shirakawa Y, Kishimoto H, Uno F, Nishizaki M, Kagawa S, Fujiwara T
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Journal Title
Cancer Immunol Immunother
Volume: 61: 1905-1916
NAID
Related Report
Peer Reviewed
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[Journal Article] Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis2012
Author(s)
Tazawa H, Yano S, Yoshida R, Yamasaki Y, Sasaki T, Hashimoto Y, Kuroda S, Ouchi M, Onishi T, Uno F, Kagawa S, Urata Y, Fujiwara T
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Journal Title
Int J Cancer
Volume: 131: 2939-2950
NAID
Related Report
Peer Reviewed
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[Journal Article] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression2012
Author(s)
Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T
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Journal Title
Eur J Cancer
Volume: 48: 2282-2291
Related Report
Peer Reviewed
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[Journal Article] Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas2011
Author(s)
Sasaki T, Tazawa H, Hasei J, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Uno F, Kagawa S, Morimoto Y, Urata Y, Ozaki T, Fujiwara T
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Journal Title
Clin Cancer Res
Volume: 17: 1828-1838
NAID
Related Report
Peer Reviewed
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[Journal Article] Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery2010
Author(s)
Kuroda S, Fujiwara T, Shirakawa Y, Yamasaki Y, Yano S, Uno F, Tazawa H, Hashimoto Y, Watanabe Y, Noma K, Urata Y, Kagawa S, Fujiwara T
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Journal Title
Cancer Res
Volume: 70: 9339-9348
Related Report
Peer Reviewed
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[Journal Article] In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy2010
Author(s)
Kojima T, Watanabe Y, Hashimoto Y, Kuroda S, Yamasaki Y, Yano S, Ouchi M, Tazawa H, Uno F, Kagawa S, Kyo S, Mizuguchi H, Urata Y, Tanaka N, Fujiwara T
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Journal Title
Ann Surg
Volume: 251: 1079-1086
Related Report
Peer Reviewed
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