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The clinical value of Circulating Tumor Cells (CTC) in patients undergoing pulmonary metastasectomy for metastatic colorectal cancer

Research Project

Project/Area Number 22791326
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionHyogo Medical University

Principal Investigator

HASHIMOTO Masaki  兵庫医科大学, 医学部, 助教 (40461074)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords循環血液中腫瘍細胞(CTC) / 結腸直腸癌肺転移 / 循環血液中腫瘍細胞(CTC / 循環腫瘍細胞 / 循環内皮細胞 / 肺転移 / 手術
Research Abstract

In this context, we conducted a prospective study to evaluate whether preoperative Circulating tumor cells (CTC)-count predicts survival after pulmonary metastasectomy in patients with metastatic colorectal cancer. Preoperative CTC-count was quantitatively evaluated with a 7.5-mL of peripheral blood sample using CellSearchTM system. Based on previously published criteria, patients were divided into favorable group and unfavorable group according to preoperative CTC-count of < 3 or ≧ 3 /7.5mL, respectively. The estimated 5-year survival rates were 80.4% in favorable group (n=50) and 0% in unfavorable group (n=2). There was a significant difference in postoperative survival between favorable and unfavorable groups (p<0.001). An elevated preoperative CTC-count (CTC≧3 /7.5mL) is an independent poor prognostic factor in patients with metastatic colorectal cancer. Pulmonary metastasectomy in such cases should be reconsidered even when they meet conventional surgical criteria.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2010

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] HasegawaCirculating Tumor Cells as a Potential Biomarker in Selecting Patients for PulmonaryMetastasectomy from Colorectal Cancer: Report of a Case2012

    • Author(s)
      M. Hashimoto, F. Tanaka, K. Yoneda, N. Kondo, T. Takuwa, S. Matsumoto, A. Kuroda M. Noda, N. Tomita, S.
    • Journal Title

      Case Reports in Oncology

      Volume: 5 Issue: 3 Pages: 542-545

    • DOI

      10.1159/000343677

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺分画症を合併したScimitar症候群の一手術例2010

    • Author(s)
      橋本昌樹, 他
    • Journal Title

      日本呼吸器外科学会雑誌

      Volume: 24 Pages: 30-4

    • NAID

      10026485191

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 胸膜外肺全摘術における胸膜外剥離2010

    • Author(s)
      橋本昌樹, 他
    • Journal Title

      胸部外科

      Volume: 63 Pages: 692-6

    • Related Report
      2010 Annual Research Report
  • [Presentation] Endbronchial Ultrasound-Transbronchial fine needle Aspiration (EBUS-TBNA) as a Modern Gold Standard for Clinical N2 (c-N2) Lung Cancer Patients.2010

    • Author(s)
      Hashimoto M, 他
    • Organizer
      4^<th> Asia Pacific Lung Cancer Conference
    • Place of Presentation
      Seoul
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 多発性骨髄腫により心アミロイドーシスを合併した肺癌の1手術例2010

    • Author(s)
      橋本昌樹, 他
    • Organizer
      第51回日本肺癌学会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科における降下性縦隔炎12例とその成績2010

    • Author(s)
      橋本昌樹, 他
    • Organizer
      第63回日本胸部外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discrepancy between clinical and pathological stages in patients undergoing extrapleural pneumonectomy for malignant pleural mesothelioma.2010

    • Author(s)
      Hashimoto M, 他
    • Organizer
      The 10^<th> International Conference of the International mesothelioma Interest Group
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] BNP is a useful biomarker for cardiac condition after EPP.2010

    • Author(s)
      Hashimoto M, 他
    • Organizer
      The 10^<th> International Conference of the International mesothelioma Interest Group (IMIG2010)
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 超音波気管支内視鏡検査(EBUS-TBNA)自験例122例の成績2010

    • Author(s)
      橋本昌樹, 他
    • Organizer
      第33回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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