Development of new therapeutic for epilepsy using convection enhanced delivery

• Project/Area Number: 22791330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: IWASAKI Masaki 東北大学, 病院, 助教 (00420018)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 医療・福祉 / 外科 / 神経科学 / 脳神経疾患 / Epilepsy / Surgery / Convection-enhanced delivery / Levetiracetam / Antiepileptic drugs / Electrocephalogram / Hippocampus / Antiepileptic drug / Electroencephalogram

Research Abstract

This study was designed for development of new therapeutics of intractable epilepsy. Convection-enhanced delivery (CED)is the method for delivering drugs from thin catheter tip directly into brain parenchyma with slow infusion rate. We performed CED of antiepileptic drug Levetiracetam to the hippocampus of rats with acute seizures. The Levetiracetam CED significantly reduced the occurrence and the duration of seizures. The animals showed no neurological deficits after the treatment. CED may be promising as a less invasive surgical treatment of epilepsy.

Research Products

• [Journal Article] Complete remission of seizures after corpus callosotomy
  • Author(s): Iwasaki M, Uematsu M, Sato Y, Nakayama T, Haginoya K, Osawa S, Itabashi H, Jin K, Nakasato N, Tominaga T
  • Journal Title: J Neurosurg Ped Volume: (in press)
  • Peer Reviewed
• [Presentation] オプトジェネティクスを用いた新たなけいれんモデル (2012)
  • Author(s): 大沢伸一郎
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-30
• [Presentation] Convection enhanced delivery of levetiracetam for trea-tment of epilepsy (2010)
  • Author(s): Shin-ichiro Osawa, Masaki Iwasaki, Ryuta Saito, Shin-ichiro Sugiyama, Nobukazu Nakasato, Teiji Tominaga
  • Organizer: 64nd Annual Meeting of American Epilepsy Society
  • Place of Presentation: San Anto-nio, Tx, USA
  • Year and Date: 2010-12-06
• [Presentation] Convection enhanced delivery of levetiracetam for treatment of epilepsy (2010)
  • Author(s): 大沢伸一郎、岩崎真樹、齋藤竜太
  • Organizer: 第64回アメリカてんかん学会
  • Place of Presentation: サンアントニオ、米国
  • Year and Date: 2010-12-06
• [Presentation] Convection-enhanced delivery法を用いたてんかん制御の試み (2010)
  • Author(s): 大沢伸一郎、岩崎真樹、齋藤竜太、杉山慎一郎、中里信和、冨永悌二
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-10-14
• [Presentation] Convection-enhanced delivery法による新しいてんかん治療の試み (2010)
  • Author(s): 大沢伸一郎、岩崎真樹、齋藤竜太、杉山慎一郎、冨永悌二
  • Organizer: 第11回日本分子脳神経外科学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-08-27