Neuroprotective mechanism of bone marrow mesenchymal stem cells via immune regulation of brain
Project/Area Number |
22791357
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Cerebral neurosurgery
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Research Institution | Showa University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 実験脳外科学 / 骨髄間葉系幹細胞 / 神経損傷 / マクログリア / 脳梗塞 / 脳虚血 / 再生医学 / マイクログリア / 脊髄損傷 / 免疫調節 / 培養細胞 / 神経細胞死 |
Research Abstract |
It has been suggested that mesenchymal stem cells (MSCs) suppress neuronal injury by collaboration with microglial cells. However, there are still unclear that the effects are direct regulation. In present study, we determined effect of hMSCs on in vitro mixed culture and in vivo spinal cord injury (SCI) model. Resulting, hMSCs decreased an inflammation marker, NO in the cell number dependent fashion. Moreover, implantation of the hMSCs one day after SCI decreased significantly motor deficit and injury volume.
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Establishment and Characterization of Primary Adult Microglial Culture in Mice2013
Author(s)
Ohtaki H, Tsumuraya T, Song D, Sato A, Ohara K, Miyamoto K, Nakano H, Kiriyama K, Dohi K, Hiraizumi H, Matsunaga M, Shioda S
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Journal Title
Acta Neurochir Suppl
Volume: 118
Pages: 49-54
DOI
ISBN
9783709114339, 9783709114346
Related Report
Peer Reviewed
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[Journal Article] Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor2010
Author(s)
Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S
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Journal Title
J Mol Neurosci
Volume: 42(3)
Issue: 3
Pages: 397-403
DOI
Related Report
Peer Reviewed
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[Journal Article] Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice2010
Author(s)
Mori H, Nakamachi T, Ohtaki H, Yo f u S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S.
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Journal Title
Circ J.
Volume: 74(6)
Pages: 1183-90
NAID
Related Report
Peer Reviewed
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[Journal Article] Nucleoprotein Diet Ameliorates Arthritis Symptoms in Mice Transgenic for Human T-Cell Leukemia Virus Type I (HTLV-1)2010
Author(s)
Ohtaki H, Yofu S, Nakamachi T, Satoh K, Shimizu A, Mori H, Sato A, Iwakura Y, Matsunaga M, Shioda S
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 46
Issue: 2
Pages: 93-104
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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[Journal Article] Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain2010
Author(s)
Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N, Baba A, Shioda S
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Journal Title
Acta Neurochir Suppl
Volume: 106
Pages: 43-6
DOI
ISBN
9783211987582, 9783211988114
Related Report
Peer Reviewed
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[Journal Article] Regulation of Oxidative Stress by Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Mediated by PACAP Receptor.2010
Author(s)
Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S.
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Journal Title
J Mol Neurosci
Volume: 42
Pages: 397-403
Related Report
Peer Reviewed
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[Journal Article] Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice.2010
Author(s)
Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S.
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Journal Title
Circ J.
Volume: 74
Pages: 1183-1190
NAID
Related Report
Peer Reviewed
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[Journal Article] Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain.2010
Author(s)
Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N, Baba A, Shioda S
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Journal Title
Acta Neurochir Suppl
Volume: 106
Pages: 43-46
Related Report
Peer Reviewed
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[Journal Article] Establishment and characterization of primary adult microglial culture in mice
Author(s)
Ohtaki H, Tsumuraya T, Song D, Sato A, Ohara K, Miyamoto K, Nakano H, Kiriyama K, Dohi K, Hiraizumi Y, Matsunaga M, Shioda S
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Journal Title
Acta Neurochirurgica Suppl
Volume: (印刷中)
Related Report
Peer Reviewed
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[Presentation] The anti-inflammatory property of human bone marrow-derived mesenchymal stem cells is preserved in late-passage cultures2013
Author(s)
Ohtaki H, Song D, Tsumuraya T, Miyamoto K, Shibato J, Rakwal R, Xu Z, Inoue T, Shioda S
Organizer
6th International Symposium on mesenchymal stem/progenitor cells
Place of Presentation
College Station, TX, USA
Year and Date
2013-05-03
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[Presentation] Interleukin-1 (IL-1) may contribute to develop classical and alternative activation of microglia/macrophages after spinal cord injury2012
Author(s)
Ohtaki H, Sato A, Tsumuraya T, Song D, Miyamoto K, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S
Organizer
11th International Society of NeuroImmunology Congress
Place of Presentation
Boston, MA, USA
Related Report
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[Presentation] PACAP誘導性の涙液分泌におけるアクアポリン5の役割2012
Author(s)
中町智哉,会沢洋一,大滝博和,養父佐知子,関保,和田悦洋,加賀美信幸,荒田悟,新谷紀人,橋本均,馬場明道,塩田清二
Organizer
第117回日本解剖学会総会・全国学術集会
Place of Presentation
甲府,山梨
Related Report
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[Presentation] Suppression of oxidative stress on PACAP might involve in the neuroprotection2011
Author(s)
Ohtaki H, Miyamoto K, Tsumuraya T, Kiriyama K, Nakano H, Song D, Nakamachi T, Hiraizumi Y, Matsunaga M, Shioda S
Organizer
Satellite Symposium of the 20th Annual Meeting of the Israel Society for Neuroscience Basic and Clinical Research of GPCRs
Place of Presentation
Eilat, Israel
Year and Date
2011-12-13
Related Report
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[Presentation] The exogenous PACAP is possible modulator of the activation of retinal microglia/macrophage in the injured retina2011
Author(s)
Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S
Organizer
Satellite Symposium of the 20th Annual Meeting of the Israel Society for Neuroscience Basic and Clinical Research of GPCRs
Place of Presentation
Eilat, Israel
Year and Date
2011-12-13
Related Report
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[Presentation] The exogenous PACAP is possible modulator of the activation of retinal microglia/macrophage in the injured retina Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S2011
Author(s)
Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S
Organizer
Satellite Symposium of the 20th Annual Meeting of the Israel Society for Neuroscience Basic and Clinical Research of GPCRs
Place of Presentation
Eilat, Israel
Year and Date
2011-12-13
Related Report
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[Presentation] Edaravone suppressed secondary neuronal cell damage after traumatic brain injury in mice2011
Author(s)
Miyamoto K, Ohtaki H, Dohi K, Song D, Tsumuraya T, Nakano H, Kiriyama K, Kageyama H, Aruga T, Shioda S
Organizer
Neuroscience 2011
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] PACAP stimulates the lacrimation via aquaporine 5 translocation in mouse2011
Author(s)
Nakamachi T, Aizawa Y, Ohtaki H, Seki T, Wada Y, Kagami N, Arata S, Hashimoto H, Shintani N, Baba A, Farkas J, Reglodi D, Shioda S
Organizer
The 10th International Symposium on VIP-PACAP and Related Peptides
Place of Presentation
Eilat, Israel
Related Report
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[Presentation] The retinoprotective effect of exogenous PACAP involves a modulation of retinal microglia/macrophage2011
Author(s)
Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S
Organizer
The 10th International Symposium on VIP-PACAP and Related Peptides
Place of Presentation
Eilat, Israel
Related Report
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[Presentation] The retinoprotective effect of exogenous PACAP involves a Modulation of retinal microglia/macrophage2011
Author(s)
Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S
Organizer
The 10th International Symposium on VIP-PACAP and Related Peptides
Place of Presentation
Eilat, Israel
Related Report
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[Presentation] The roles of Gp91phox (NOX2) expressed in classical activated microglia after traumatic brain injury2010
Author(s)
Dohi K, Ohtaki H, Kazue S, Nakamachi T, Yo f u S, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
Organizer
10th International Congress of Neuroimmunology (ISNI 2010)
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] The roles of Gp91phox (NOX2) expressed in classical activated microglia after traumatic brain injury.2010
Author(s)
Dohi K, Ohtaki H, Kazue S, Nakamachi T, Yofu S, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
Organizer
10th International Congress of Neuroimmunology (ISNI 2010)
Place of Presentation
Barcelona, Spain
Related Report
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