| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
It has been suggested that mesenchymal stem cells (MSCs) suppress neuronal injury by collaboration with microglial cells. However, there are still unclear that the effects are direct regulation. In present study, we determined effect of hMSCs on in vitro mixed culture and in vivo spinal cord injury (SCI) model. Resulting, hMSCs decreased an inflammation marker, NO in the cell number dependent fashion. Moreover, implantation of the hMSCs one day after SCI decreased significantly motor deficit and injury volume.
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