Evaluation of RANKL reverse signaling as therapeutic targets for osteoporosis
| Project/Area Number |
22791364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HONMA Masashi 東京大学, 医学部附属病院, 助教 (60401072)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨・軟骨代謝学 / シグナル伝達 / 発現制御 / 生体分子 / 骨粗鬆症 / 骨芽細胞 / 破骨細胞 / 双方向シグナル / RANKL |
|---|
| Research Abstract |
Microtubules are necessary for RANKL translocation to the osteoblastic cell surface and Rac1/Cdc42-IQGAP1-CLIP170 are indicted to be involved in the reconstruction of microtubules towards the stimulated area. Moreover, mTORC2 is indicated to be activated in response to RANK stimulation and regulate Racc1/Cdc42 activation.
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Report
(3 results)
Research Products
(9 results)
