A novel therapeutic strategy with SIRT1-targeted therapy for musculoskeletal malignancies.
Project/Area Number |
22791378
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Kobe University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
Keywords | 骨軟部肉腫 / SIRT1 / 長寿因子 / 抗アポトーシス / アポトーシス / SIRT1 |
Research Abstract |
To establish the molecular targeting therapy focused on an anti-aging gene, SIRT1 for human musculoskeletal malignancies, we assessed the expression of SIRT1 in various musculoskeletal tumors, and evaluated the effect of SIRT1 inhibition in human MFH cell lines. SIRT1 highly expressed in tissues from osteosarcomas and MFHs, compared to benign schwannomas, and the inhibition of SIRT1 decreased the cell viability in human MFH cells. Our findings strongly indicate that SIRT1 can be a novel therapeutic target for molecular targeting therapy on human musculoskeletal malignancies, and further studies on the roles of SIRT1 in musculoskeletal malignancies will be needed.
|
Report
(4 results)
Research Products
(24 results)
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[Journal Article] Transcutaneous application of carbon dioxide (CO2) enhances chemosensitivity by reducing hypoxic conditions in human malignant fibrous histiocytoma2012
Author(s)
Onishi Y, Kawamoto T, Ueha T, Hara H, Fukase N, Toda M, Harada R, Sakai Y, Miwa M, Nishida K, Kurosaka M, Akisue
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Journal Title
J Cancer Sci Ther
Volume: 4
Pages: 174-181
Related Report
Peer Reviewed
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[Journal Article] Transcutaneous application of carbon dioxide (CO(2)) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo2012
Author(s)
Onishi Y, Kawamoto T, Ueha T, Kishimoto K, Hara H, Fukase N, Toda M, Harada R, Minoda M, Sakai Y, Miwa M, Kurosaka M, Akisue T
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Journal Title
Related Report
Peer Reviewed
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