Efficient derivation of osteoprogenitor cells from induced pluripotent stem cells for bone regeneration

Research Project

Project/Area Number	22791379
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Kobe University
Principal Investigator	LEE Sangyang 神戸大学, 医学部附属病院, 特定助教 (40533732)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	四肢機能再建学 / 再生医療 / iPS細胞 / 骨分化 / 骨再生 / 偽関節 / 骨折 / マウスiPS細胞 / 骨分化誘導 / 胚葉体
Research Abstract	The novel direct-plating method described here provides a significant technical advance over conventional methods of iPSC. induced osteoprogenitor cells by avoiding the embryonic body formation that often leads to heterogeneous and unpredictable osteogenic differentiation. Because of simplicity, our novel direct-plating method could be amenable to large-scale production of osteoprogenitor cells for bone regeneration.

Report

(3 results)