The effect of human mesenchymal stem cell and risedronate on TNF-alpha-induced osteoclast differentiation
| Project/Area Number |
22791384
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
FUJITA Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20423288)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 破骨細胞 / 間葉系幹細胞 / ビスホスフォネート / 顎骨壊死 / ビスフォスフォネート |
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| Research Abstract |
We investigated the effect of human bone marrow mesenchymal stem cell(hMSC) and bisphosphonate on inflammatory cytokine-induced osteoclast differentiation. Our findings showed that osteoclast differentiation by TNF-alpha was suppressed by hMSC and the suppression was inhibited by bisphosphonate.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells2011
Author(s)
Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, Inoue K, Shuin T, Sasaki J, Inoue M, Utsumi K
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Journal Title
Mol Cell Biochem
Volume: 358(1-2)
Pages: 297-307
Related Report
Peer Reviewed
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[Journal Article] Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells2011
Author(s)
Fujita H, Kurokawa K, Ogino T, Ono M, Yamamoto M, Oka T, Nakanishi T, Kobayashi N, Tanaka N, Ogawa T, Suzaki E, Utsumi K, Sasaki J.
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Journal Title
Basic Clin Pharmacol Toxicol.
Volume: 109(2)
Issue: 2
Pages: 78-84
DOI
Related Report
Peer Reviewed
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