The effects of mutated MMP2 on bone and joint

• Project/Area Number: 22791386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: FUKUSHI Jun-ichi 九州大学, 大学病院, 助教 (40444806)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨溶解症 / 骨破壊 / MMP2 / MMP２

Research Abstract

Mutations in MMP2 gene results in unique skeletal phenotype called osteolysis, which is characterized by multiple joint distraction and severe osteoporosis. The pathology of joint damages in osteolysis mimics rheumatoid synovitis, however, the underlining molecular mechanism how inactivated mutation in MMP2 results in osteolysis is largely unknown. In this study, we tried to develop an animal model for osteolysis. We have made a conditional transgenic mouse carring an mutated MMP2 gene, which can be over-expressed under specific condition. This mouse would be useful for understanding the roles of MMP2 during the development of osteolysis.