| Project/Area Number |
22791425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | テトラヒドロビオプテリン / グアニル酸シクロヒドロラーゼ1 / 痛覚伝達 / 後根神経節 / アセチルコリン / 神経障害痛のラットモデル / pChAT / dorsal root ganglion / GTP cyclohydrolase 1 |
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| Research Abstract |
GCH1 is the first and rate-limiting enzyme in the biosynthetic pathway of tetrahydrobiopterin(BH4), an important cofactor for the synthesis of several modulator in pain neurotransmission. Recently, the importance of GCH1 as pain marker has been recognized. Here, the role of BH4 has been investigated in the DRG of rat model of pain and in naive rat treated with cholinergic agonist. Experimental results shown that cholinergic system interact with tetrahydrobiopterin metabolism to decrease pain sensation. This results suggested that an increase in GCH1 regulatory protein(GFRP) expression is involved in analgesic effect by GCH1 inhibitor.
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