Analgesia mediated by enhancement of descending noradrenergic neuron with GDNF
| Project/Area Number |
22791457
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経障害性疼痛 / GDNF / 下行性疼痛抑制 / ノルアドレナリン / 青斑核 |
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| Research Abstract |
Administration of substance P into locus coeruleus, a nucleus constituting descending noradrenergic neurons, attenuated neuropathic pain via NK1 receptor activation. In addition, administration of glial cell line-derived neurotrophic factor (GDNF) into the locus coeruleus persistently attenuated the neuropathic pain. These analgesic effects were mediated by noradrenergic descending inhibition.
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Report
(4 results)
Research Products
(28 results)
