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Establishment of a novel biomarker of testicular cancer

Research Project

Project/Area Number 22791463
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionTohoku University

Principal Investigator

YAMADA Shigeyuki  東北大学, 病院, 助教 (60509256)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords精巣腫瘍 / セミノーマ / バイオマーカー / DNMT3A遺伝子
Research Abstract

We conducted flow cytometry analysis about DNMT3A antibody of mouse and rabbit. There was no reaction with Hs1 cell arriving from normal testicular tissues. However, there was a significant reaction with NCCIT cell arriving from testicular cancer tissues, and this reaction was amplified by Triton preparation. We also conducted immunohistochemical analysis of DNMT3A for human testicular seminoma tissues, and confirmed that human seminoma cells were positively stained.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (14 results) Book (5 results) Remarks (3 results)

  • [Journal Article] Lumbar incisional hernia of the kidney after laparoscopic adrenalectomy in a patient with Cushing's syndrome2011

    • Author(s)
      Miyazato M, Yamada S, Kaiho Y, Ito A, Ishidoya S, Arai Y
    • Journal Title

      Urol Int

      Volume: 87 Pages: 369-71

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical outcomes of laparoscopic adrenalectomy for patients with Cushing's and subclinical Cushing's syndrome : a single center experience2011

    • Author(s)
      Miyazato M, Ishidoya S, Satoh F, Morimoto R, Kaiho Y, Yamada S, Ito A, Nakagawa H, Ito S, Arai Y
    • Journal Title

      International Urology and Nephrology

      Volume: 43巻 Pages: 975-981

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Renal hypothermia using ice-cold saline for retroperitoneal laparoscopic partial nephrectomy : evaluation of split renal function with technetium-99m-dimercaptosuccinic acid renal scintigraphy2011

    • Author(s)
      Arai Y, Kaiho Y, Saito H, Yamada S, Mitsuzuka K, Miyazato M, Nakagawa H, Ishidoya S, Ito A
    • Journal Title

      Urology

      Volume: 77巻 Pages: 814-818

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predicting the severity of acute urinary toxicity after brachytherapy with iodine-125 for localized prostate cancer2011

    • Author(s)
      Takeda K, Jingu K, Koto M, Fujimoto K, Narazaki K, Kubozono M, Saito H, Yamada S, Mitsuduka K, Ishidoya S, Ariga H, Arai Y, Yamada S
    • Journal Title

      The Tohoku journal of experimental medicine

      Volume: 223巻 Pages: 55-60

    • NAID

      10027806657

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 副腎癌との鑑別が困難だった後腹膜Ewing肉腫の1例2011

    • Author(s)
      佐藤真彦, 宮里実, 山田成幸、荒井陽一
    • Journal Title

      泌尿器科紀要

      Volume: 57巻 Pages: 303-307

    • NAID

      40018861642

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor.2010

    • Author(s)
      Hatakeyama S, Kyan A, Yamamoto H, Okamoto A, Sugiyama N, Suzuki Y, Yoneyama T, Hashimoto Y, Koie T, Yamada S, Saito H, Arai Y, Fukuda M, Ohyama C
    • Journal Title

      Int J Cancer

      Volume: 127巻 Pages: 1052-1059

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor.2010

    • Author(s)
      Hatakeyama S, Kyan A, Yamamoto H, Yamada S, Saito H, Arai Y, Fukuda M, Ohyama C.
    • Journal Title

      Int J Cancer

      Volume: 127(5) Pages: 1052-1059

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 精巣腫瘍Update ~ リスクに応じた適切な治療を目指して~2012

    • Author(s)
      山田成幸、ミニレクチャー
    • Organizer
      第12回泌尿器科CPC
    • Place of Presentation
      仙台
    • Year and Date
      2012-02-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 精巣腫瘍の治療における栄養支持療法(NST)の有用性について2011

    • Author(s)
      山田成幸
    • Organizer
      第19回東北EBMフォーラム
    • Place of Presentation
      仙台
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 若年女性の尿膜管癌に対し腹腔鏡操作と下腹部Pfannenstiel切開によるアプローチを併用し、整容的な手術を施行し得た1例2011

    • Author(s)
      山田成幸
    • Organizer
      第25回日本泌尿器内視鏡学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 難治性精巣腫瘍に対する救済化学療法としてのDIN療法の治療成績2011

    • Author(s)
      山田成幸
    • Organizer
      第49回日本癌治療学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 腎機能障害を呈する尿路上皮癌へのGemcitabin-Carboplatin療法の安全性と有用性の検討2011

    • Author(s)
      三塚浩二, 山田成幸, 斎藤英郎, 伊藤明宏, 石戸谷滋人, 荒井陽一
    • Organizer
      第49回日本癌治療学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌に対する根治的前立腺摘除術後の排尿症状改善と前立腺サイズとの関連性2011

    • Author(s)
      宮里実, 大原慎也, 三塚浩二, 山田成幸, 齋藤英郎, 海法康裕, 伊藤明宏, 中川晴夫, 石戸谷滋人, 斎藤誠一, 荒井陽一
    • Organizer
      第49回日本癌治療学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] BEP療法におけるクリニカルパスの導入と支持療法の工夫について2011

    • Author(s)
      山田成幸
    • Organizer
      第76回日本泌尿器科学会東部総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Nutrition support therapy can reduce perioperative complications of open post-chemotherapy RPLND for metastatic germ cell cancer2011

    • Author(s)
      Yamada S
    • Organizer
      28th Korea-Japan Urological Congress
    • Place of Presentation
      水原、韓国
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 難治性精巣腫瘍進行症例に対する導入化学療法と管理2011

    • Author(s)
      山田成幸
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 歯科領域の感染合併により、sunutinib内服中に著明な血小板減少症を来たした進行腎癌の1例2010

    • Author(s)
      山田成幸
    • Organizer
      第62回日本泌尿器科学会西日本総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 東北大学病院における対側精巣生検および両側精巣腫瘍症例の臨床的検討2010

    • Author(s)
      山田成幸
    • Organizer
      第48回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 精巣腫瘍Update~ 診療ガイドラインの解説と東北大学の治療成績~2010

    • Author(s)
      山田成幸
    • Organizer
      宮城県泌尿器科医会講演会
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Improved outcome for ' Poor-prognosis' germ cell cancer at a single center in Japan ~ a country with low incidence~2010

    • Author(s)
      Yamada S
    • Organizer
      第109回東北泌尿器科談話会泌尿器科セミナー
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Improved outcome for poor-prognosis metastatic germ cell cancer : a single center experience in Japan2010

    • Author(s)
      Yamada S
    • Organizer
      the AUA Annual Meeting 2010
    • Place of Presentation
      San Francisco USA
    • Year and Date
      2010-05-31
    • Related Report
      2011 Final Research Report
  • [Book] POOR RISK精巣腫瘍に対する外科的治療-適応とタイミング-, 泌尿器外科 POOR RISK 精巣腫瘍の再考-さらなる治療成績の向上を目指して2012

    • Author(s)
      山田成幸
    • Publisher
      医学図書出版
    • Related Report
      2011 Final Research Report
  • [Book] エビデンスに基づいたがん治療エキスパートマニュアル各論16前立腺がん2012

    • Author(s)
      山田成幸
    • Publisher
      総合医学社
    • Related Report
      2011 Final Research Report
  • [Book] 泌尿器外科POOR RISK精巣腫瘍の再考-さらなる治療成績の向上を目指して「POOR RISK精巣腫瘍に対する外科的治療-適応とタイミング-」2012

    • Author(s)
      山田成幸
    • Publisher
      医学図書出版
    • Related Report
      2011 Annual Research Report
  • [Book] 泌尿器科薬物療法1st VISIT, 2nd VISIT I感染・炎症性疾患:急性腎盂腎炎2011

    • Author(s)
      山田成幸
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 精巣癌の手術療法b)化学療法後の残存腫瘍切除2010

    • Author(s)
      山田成幸
    • Publisher
      日本臨床社
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科医科学専攻外科病態学講座泌尿器科学教室

    • URL

      http://www.uro.med.tohoku.ac.jp/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.uro.med.tohoku.ac.jp/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.uro.med.tohoku.ac.jp/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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