The inhibition of lung metastasis of renal cell carcinoma by the regulation of premetastatic niche

• Project/Area Number: 22791498
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: KANEKO Gou 慶應義塾大学, 医学部, 助教 (20445266)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腎癌 / 転移 / 微小環境

Research Abstract

It was suggested that humoral factors produced from the primary cancer lesion induced macrophage and formed premetastatic niche where was suitable for the metastasis. Further evaluation was needed about the effect of ARB to microenviroment of metastatic lesion before tumor metastasis.