| Project/Area Number |
22791567
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
HAYASHI Kentaro 筑波大学, 人間総合科学研究科, 研究生
TABUCHI Keiji 筑波大学, 医学医療系, 講師
HARA Akira 筑波大学, 医学医療系, 教授
YAMAMOTO Masayuki 東北大学, 大学院・医学系研究科, 教授
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 転写因子 / GATA3 / 内耳 / 発生 |
|---|
| Research Abstract |
Because the transcriptional factor GATA3 express in otic vesicles and inner ears, it is suggested that GATA3 is important for the developmental pathway of the inner ear. Little is known about the function of GATA3 in developmental pathway because of lethality of Gata3 knockout mouse. Then, we used the new approach, a transgenic rescue technique. This clarified that part of Gata3-null-ears occurs to inner ear malformation. This result indicates GATA3 is indispensable to form the inner ear from the otic vesicle.
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