• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Glutamine-glutamate recycle system in the inner ear

Research Project

Project/Area Number 22791588
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionShinshu University

Principal Investigator

OGUCHI Tomohiro  信州大学, 医学部, 助教 (10377640)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords耳科学 / グルタミン / 神経伝達物質 / 内耳 / 難聴 / 前庭 / グルタミン酸 / グルタミン・グルタミン酸サイクル / 遺伝子発現
Research Abstract

Glutamate has been implicated in signal transmission between inner hair cells and afferent fibers of the organ of Corti. The inner hair cells are enriched in glutamate and the postsynaptic membranes express AMPA glutamate receptors. However, it is not known whether inner hair cells contain a mechanism for glutamate replenishment. Such a mechanism must be in place to sustain glutamate neurotransmission. Here we provide RT -PCR and immunofluorescence data indicating that system A transporter 1 (SLC38A1), which is associated with neuronal glutamine transport and synthesis of the neurotransmitters GABA and glutamate in CNS, is expressed in inner hair cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Inner hair cells of mice express the glutamine transporter SAT12012

    • Author(s)
      Oguchi T, Suzuki N, Hashimoto S, Chaudhry GA, Chaudhry FA, Usami S,Ottersen OP.
    • Journal Title

      Hear Res

      Volume: 292(1-2) Issue: 1-2 Pages: 59-63

    • DOI

      10.1016/j.heares.2012.07.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] The effect of microgravity on gene expression in the vestibular end-organs. Otoconin 90 was up-regulated by microgravity2012

    • Author(s)
      Oguchi T,Nishio S,Suzuki N, Takumi Y, Usami S
    • Organizer
      27th Barany Society Meeting
    • Place of Presentation
      Uppsala,Sweden
    • Related Report
      2012 Final Research Report
  • [Presentation] The effect of Microgravity on Gene Expression in the Vestibular Endorgans2011

    • Author(s)
      Oguchi T. Suzuki N. Takumi Y. Usami S.
    • Organizer
      8TH Symposium on the Role of the Vestibular Organs in Space Explorartion
    • Place of Presentation
      ヒューストン,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Vestibular organs express the glutamine transporters2010

    • Author(s)
      Oguchi T
    • Organizer
      Sixth International Symposium on Meniere's Disease and Inner Ear Disorders.
    • Place of Presentation
      京都
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi