Clarification of oxygen sensor system of the mouse trachea epithelia

• Project/Area Number: 22791598
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: ISHIDA Yusuke 大阪大学, 医学系研究科, 講師 (30381809)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 酸素センサー / 低酸素 / 味蕾様構造物 / 気管上皮 / in situ hybridization / 脳・神経 / 神経科学 / 免疫組織化学

Research Abstract

Oxygen is essential for life, however, oxygen sensor and the transmission system are still unknown. We hypothesized that oxygen is sensed on trachea epithelia and began to research on oxygen-sensing system of the mouse trachea epithelia. Our results indicated that taste bud-like structure in the trachea epithelia is oxygen sensor. Furthermore, it was indicated that ATP and ATP receptor play crucial roles on oxygen-sensing systems of the mouse trachea epithelia.

Research Products

• [Presentation] Expression of serotonin 3A and 3B receptor in the rat geniculateganglion (2012)
  • Author(s): 石田 雄介
  • Organizer: 日本解剖学会
  • Place of Presentation: 山梨大学
• [Presentation] Double in situhybridization 法を用いたラット膝神経節におけるセロトニン 3A と 3B 遺伝子の発現の検討 (2011)
  • Author(s): 石田 雄介
  • Organizer: 日本神経化学会
  • Place of Presentation: 金沢大学
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/