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Morphological analyses of Common Marmoset(Callithrix jacchus) cochlea and temporal bone for future translational researches

Research Project

Project/Area Number 22791628
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

FUJIOKA Masato  慶應義塾大学, 医学部, 助教 (70398626)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords耳科学 / トランスレーショナルリサーチ / 実験動物学 / 比較解剖学 / 画像診断
Research Abstract

Detailed morphology of Common Marmoset cochlea and temporal bone was investigated. Based on the anatomical findings, we established several surgical landmarks that can be used for its otologic surgery. On the other hand, by using 7T-MRI with or without cryogenic probe, we successfully visualized auditory pathways from cochlear, cochlear nerve, cochlear nucleus to the nuclei in the mid-brain including superior olive nucleus, lateral laminicus and inferior colliculus. The results will be useful for the future translational researches with the species.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (17 results) Book (1 results)

  • [Journal Article] 経頭蓋磁気刺激による耳鳴治療2012

    • Author(s)
      小川郁, 新田清一, 神崎晶, 岡本康秀, 南修司郎, 渡部高久, 藤岡正人, 和佐野浩一郎, 本村朋子, 若林聡子, 稲垣洋三, 斉藤秀行, 井上泰宏
    • Journal Title

      耳鼻咽喉科展

      Volume: 54巻5号 Pages: 258-266

    • NAID

      130004546370

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pranlukast dry syrup inhibits symptoms of Japanese cedar pollinosis in children using OHIO Chamber2012

    • Author(s)
      Wakabayashi K, Hashiguchi K, Kanzaki S, Fujioka M, Tanaka N, Kawashima K, Suematsu K, Yamamotoya H, Iwasaki M, Gotoh M, Horibe S, Naito K, Okubo K
    • Journal Title

      Allergy Asthma Proc

      Volume: 33(1) Pages: 102-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] OHIO Chamberにおけるスギ・ヒノキ科花粉連続曝露に対するベポタスチンベシル酸塩OD錠の効果-Artificial exposure Chamber(OHIO) Trial Inhibitory effect of bepotastine-OD for Nasal allergy II (ACTION II study)-2011

    • Author(s)
      神崎晶、橋口一弘、若林健一郎、藤岡正人、末松潔親、大久保公裕
    • Journal Title

      新薬と臨床

      Volume: 54巻5号 Pages: 258-266

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and function of Sox21 during mouse cochlea development2011

    • Author(s)
      Hosoya M, Fujioka M, Matsuda S, Ohba H, Shibata S, Nakagawa F, Wakabayashi K, Saga Y, Ogawa K, Okano HJ, Okano H
    • Journal Title

      Neurochem Res

      Volume: 36(7) Pages: 1261-1269

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Edge AS、Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation2011

    • Author(s)
      Fujioka M, Tokano H, Fujioka SK, Okano H
    • Journal Title

      J. Clin Invest

      Volume: 121(6) Pages: 2462-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Edge AS(double first author)、Notch Signaling Alters Sensory of Neuronal Cell Fate Specification of Inner Ear Stem Cells2011

    • Author(s)
      Fujioka M, Jeon SJ, Kim SC
    • Journal Title

      J. Neurosci

      Volume: 31(23) Pages: 8351-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Balance Dysfunction Resulting From Acute Inner Ear Energy Failure Is Caused Primarily by Vestibular Hair Cell Damage2011

    • Author(s)
      Mizutari K, Fujioka M, Nakagawa S, Fujii M, Ogawa K, Matsunaga T
    • Journal Title

      J. Neurosci. Res

      Volume: 31(23) Pages: 8351-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 耳硬化症Update治療と予防2011

    • Author(s)
      小川郁, 井上泰宏, 齊藤秀行, 神崎晶, 岡本康秀, 水足邦雄, 鈴木隆史, 大石直樹, 和多田有紀子, 渡部高久, 藤岡正人
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 103巻2号 Pages: 103-112

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 症例をどうみるか中耳カルチノイド腫瘍と中耳腺腫2011

    • Author(s)
      渡部高久, 鈴木隆史, 南修司郎, 和多田有紀子, 藤岡正人, 神崎晶, 齋藤秀行, 井上泰宏, 向井万起男, 小川郁
    • Journal Title

      JOHNS

      Volume: 26巻2号 Pages: 269-273

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cre/lox mediated in vivo mosaic cell ablation to generate novel mouse models of degenerative disease2011

    • Author(s)
      Fujioka M, et al
    • Journal Title

      Journal of Clinical Investigation

      Volume: 121(5)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and Function of Sox21 During Mouse Cochlea Development.2011

    • Author(s)
      Hosoya M, et al
    • Journal Title

      Neurochemical Research

      Volume: 2(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] OHIO Chamberにおけるスギ・ヒノキ科花粉連続曝露に対するベポタスチンベシル酸塩OD錠の効果-Artificial exposure Chamber(OHIO) Trial Inhibitory effect of bepotastine-OD for Nasal allergy II (ACTION II study)-2011

    • Author(s)
      神崎晶、橋口一弘、若林健一郎、藤岡正人、末松潔親、大久保公裕
    • Organizer
      第50回日本鼻科学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-12-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Tbx1発現用量と内耳発生の関連性2011

    • Author(s)
      渡部高久、神崎晶、藤岡正人、稲垣洋三、若林聡子、本村朋子、和佐野浩一郎、斎藤秀行、井上泰宏、小川郁
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Cre/loxと調節性Caspaseを用いたモザイク様細胞死モデルの樹立-病気の「なりはじめ」を科学する-2011

    • Author(s)
      藤岡正人、戸叶尚史、小川郁
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 当院耳鳴難聴外来におけるTRT単独症例(TCI使用者)の3年以上の長期経過について2011

    • Author(s)
      稲垣洋三, 神崎晶, 大石直樹, 井上泰宏, 齊藤秀行, 藤岡正人, 渡部高久, 渡邊麗子, 和佐野浩一郎, 若林聡子, 新田清一, 小川郁
    • Organizer
      第56回聴覚医学会総会・学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 耳鳴に対する新しい質問紙(THI-12、TRS、TRSw、TSS、TSSw)の計量心理学的検証2011

    • Author(s)
      和佐野浩一郎, 坂下哲史, 高橋真理子, 井上泰宏, 齊藤秀行, 神崎晶, 藤岡正人, 渡部高久, 渡邊麗子, 角南貴司子, 加藤匠子, 蒲谷嘉代子, 新田清一, 小川郁
    • Organizer
      第56回聴覚医学会総会・学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 耳硬化症疑い例に対する骨粗鬆症薬を用いた予防効果について(preliminary report)2011

    • Author(s)
      神崎晶, 小川郁, 井上泰宏, 齊藤秀行, 藤岡正人, 渡部高久, 渡辺麗子, 和佐野浩一郎
    • Organizer
      耳鼻咽喉科臨床学会
    • Place of Presentation
      長野
    • Year and Date
      2011-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 3Dビデオを用いた側頭骨解剖の教育2011

    • Author(s)
      井上泰宏, 神崎晶, 斉藤秀行, 渡部高久, 渡邊麗子, 和佐野浩一郎, 藤岡正人, 小川郁
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規高出力型半導体レーザーの耳鼻咽喉科手術臨床への応用に向けた基礎的検討(第一報)2011

    • Author(s)
      藤岡正人, 神崎晶, 井上泰宏, 齊藤秀行, 渡部高久, 渡邊麗子, 和佐野浩一郎, 小川郁
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 32列Fine-cell detector CT(FDCT)による側頭骨解剖の評価2011

    • Author(s)
      渡部高久, 神崎晶, 陣崎雅弘, 藤原広和, 和佐野浩一郎, 藤岡正人, 渡邊麗子, 斉藤秀行, 井上泰宏, 小川郁
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Van der Hoeve症候群に対するアブミ骨手術の術後成績の検討2011

    • Author(s)
      和佐野浩一郎, 神崎晶, 井上泰宏, 齊藤秀行, 渡部高久, 藤岡正人, 渡邊麗子, 小川郁
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] A transgenic mouse model for autoimmune hearing loss due to a"failure"of immunologic tolerance to the inner ear hair cell2011

    • Author(s)
      Fujioka M
    • Organizer
      HMS-Keio-Northwestern Joint meeting for inner ear autoimmunity
    • Place of Presentation
      Boston, MA
    • Year and Date
      2011-03-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規高出力型半導体レーザーの耳鼻咽喉科手術臨床への応用に向けた基礎検討2011

    • Author(s)
      藤岡正人、神崎晶、小川郁
    • Organizer
      慶應医用レーザー研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Sound generatorを用いたTRTの予後因子の検討2010

    • Author(s)
      渡部高久, 神崎晶, 井上泰宏, 齊藤秀行, 新田清一, 南修司郎, 藤岡正人, 渡邊麗子, 和佐野浩一郎, 小川郁
    • Organizer
      第56回日本聴覚医学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 内耳基礎研究の基礎講座「内耳トランスレーショナルリサーチの心強いツールたち~分子生物学から実験動物まで~」2010

    • Author(s)
      藤岡正人
    • Organizer
      第29回聴覚生理研究会(H22耳科学会)
    • Place of Presentation
      松山
    • Year and Date
      2010-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Reconstruction of external auditory canal in patient with lateral temporal bone resection : a case series of three patients Joint2010

    • Author(s)
      Fujioka M, Saito H, Inoue Y, Kanzaki S, Minami S, Watabe T, Watanabe R, Watada Y, Ogawa K
    • Organizer
      meeting-IV Consensus in Auditory Implants & V EAONO Instructional Workshop
    • Place of Presentation
      イタリア
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Cre/lox系と調節性Caspaseを用いたモザイク様細胞死モデルの樹立病気の「なりはじめ」を科学する2010

    • Author(s)
      藤岡正人, 戸叶尚史, 小川郁
    • Organizer
      第111回日本耳鼻咽喉科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Cre/loxと調節性Caspaseを用いたモザイク様細胞死モデルの樹立-病気の「なりはじめ」を科学する2010

    • Author(s)
      藤岡正人
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Book] 外来で診る耳鼻咽喉科疾患第1章耳疾患2011

    • Author(s)
      藤岡正人, 小川郁
    • Publisher
      慶応義塾大学薬学部
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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