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Identification of carcinogenesis mechanism and strategy of novel treatment by microRNA analysis in head and neck cancer or gynecological cancer

Research Project

Project/Area Number 22791630
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

UNO Kosuke  慶應義塾大学, 医学部, 助教 (20464828)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords頭頸部癌 / マイクロRNA
Research Abstract

MicroRNAs(miRNAs), showing highly disease-specific expression patterns, are promising biomarkers and novel therapeutic targets. We first examined the expression of human miRNAs in laryngeal and pharyngeal tissues using microarrays, To confirm these findings, we next performed quantitative real-time PCR(qRT-PCR) on cancer specific miRNAs and these findings were consistent with those obtained from microarrays. Finally, to explore the physiological significances of laryngeal and pharyngeal cancer-associated miRNAs, we examined the effect of these miRNAs on cell growth and viability using head and neck cancer cell line. We couldn't carry out the study about gynecological cancer in this term.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (1 results)

All 2010

All Presentation (1 results)

  • [Presentation] Disease specific miRNAs as novel therapeutic target for hypophyaryngeal cancer2010

    • Author(s)
      宇野光祐, 斎藤康一郎, 稲垣康治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report

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Published: 2010-11-30   Modified: 2016-04-21  

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