Identification of carcinogenesis mechanism and strategy of novel treatment by microRNA analysis in head and neck cancer or gynecological cancer
| Project/Area Number |
22791630
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
UNO Kosuke 慶應義塾大学, 医学部, 助教 (20464828)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部癌 / マイクロRNA |
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| Research Abstract |
MicroRNAs(miRNAs), showing highly disease-specific expression patterns, are promising biomarkers and novel therapeutic targets. We first examined the expression of human miRNAs in laryngeal and pharyngeal tissues using microarrays, To confirm these findings, we next performed quantitative real-time PCR(qRT-PCR) on cancer specific miRNAs and these findings were consistent with those obtained from microarrays. Finally, to explore the physiological significances of laryngeal and pharyngeal cancer-associated miRNAs, we examined the effect of these miRNAs on cell growth and viability using head and neck cancer cell line. We couldn't carry out the study about gynecological cancer in this term.
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Report
(3 results)
Research Products
(1 results)
