Development of macrophage migration inhibitory factor DNA vaccine against inflammatory ocular disease

Research Project

Project/Area Number	22791645
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Hokkaido University
Principal Investigator	KITAMEI Hirokuni 北海道大学, 大学院・医学研究科, 客員研究員 (90451426)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	ぶどう膜炎 / MIF / ワクチン / 眼炎症
Research Abstract	We made an effort to develop the vaccine against serious endogenous uveitis. First, mice received a DNA vaccine against proinflammatory cytokine, macrophagemigration inhibitory factor (MIF), and then the mice were immunized to induceexperimental autoimmune uveoretinitis (EAU), an animal model for humanendogenous uveitis. The severity of EAU was successfully milder after vaccinationthan controls. However, antibody levels were not elevated enough in some subjects.

Report

(4 results)