Development of macrophage migration inhibitory factor DNA vaccine against inflammatory ocular disease
| Project/Area Number |
22791645
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KITAMEI Hirokuni 北海道大学, 大学院・医学研究科, 客員研究員 (90451426)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ぶどう膜炎 / MIF / ワクチン / 眼炎症 |
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| Research Abstract |
We made an effort to develop the vaccine against serious endogenous uveitis. First, mice received a DNA vaccine against proinflammatory cytokine, macrophagemigration inhibitory factor (MIF), and then the mice were immunized to induceexperimental autoimmune uveoretinitis (EAU), an animal model for humanendogenous uveitis. The severity of EAU was successfully milder after vaccinationthan controls. However, antibody levels were not elevated enough in some subjects.
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Report
(4 results)
Research Products
(2 results)
