To investigate molecular mechanisms for dynamics of retinal angiogenesis using time-lapse imaging
| Project/Area Number |
22791654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 眼生化学 / 分子生物学 / 網膜血管新生 / タイムラプス観察 / VEGF / アクチン / glycogen synthase kinase(GSK)-3β / stromal-derived factor(SDF)-1 / glycogen synthase kinase (GSK)-3β / stromal-derived factor (SDF)-1 |
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| Research Abstract |
We established a novel time-lapse imaging for retinal angiogenesis in retinal explants. The quantification elucidated both dynamic and static phases in angiogenic sprouting. Further, we demonstrated a novel finding that SDF-1 and GSK-3βregulate the motility of vascular endothelial cells in retinal angiogenesis.
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Report
(3 results)
Research Products
(14 results)
