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Dendritic Cells Augment Choroidal Neovascularization

Research Project

Project/Area Number 22791657
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

NAKAI kei  大阪大学, 医学(系)研究科(研究院), 助教 (30546883)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords脈絡膜新生血管 / 樹状細胞 / 血管新生
Research Abstract

Age-related macular degeneration is the leading cause of irreversible vision loss among the elderly in most industrialized nations.Severe vision loss in ARMD is most commonly caused by choroidal neovascularization, wherein new vessels from the choroid invade the subretinal space through Bruch membrane.Dendritic cells are innate immune cells of hematopoietic origin that have a pivotal role in the initiation of the adaptive immune response.Although DCs have been detected in normal uvea, inflamed retina and drusen deposits, to date there has been no reports of their presence in CNV.Aside from their role in immune function, DCs have recently been shown to support angiogenesis in tumors, endometriosis and lymph nodes.We showed that DCs may play a role in the pathogenesis of CNV similar to their role in tumor growth and endometriosis.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Choroidal thickness in eyes with tilted disk syndrome.2014

    • Author(s)
      Ueno C, Gomi F, Ikuno Y, Nakai K, Sawa M, Nishida K.
    • Journal Title

      Retina

      Volume: 34 Issue: 3 Pages: 497-503

    • DOI

      10.1097/iae.0b013e3182a1ca40

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal observations in posterior scleritis using high-penetration optical coherence tomography.2014

    • Author(s)
      Uchihori H, Nakai K, Ikuno Y, Gomi F, Hashida N, Jo Y, Nishida K.
    • Journal Title

      Int Ophthalmol

      Volume: [Epub ahead of print]

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between ocular findings and preventive therapy with onset of central nervous system involvement in patients with primary vitreoretinal lymphoma.2014

    • Author(s)
      Hashida N, Nakai K, Saitoh N, Nishida K.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 252 Issue: 4 Pages: 687-93

    • DOI

      10.1007/s00417-014-2584-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic evaluation of ocular toxocariasis using high-penetration optical coherence tomography.2014

    • Author(s)
      Hashida N, Nakai K, Nishida K.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 8 Issue: 1 Pages: 16-21

    • DOI

      10.1159/000358191

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser-induced choroidal neovascularization in mice attenuated by deficiency in the apelin-APJ system2013

    • Author(s)
      Hara C, Kasai A, Gomi F, Satooka T, Sakimoto S, Nakai K, Yoshioka Y, Yamamuro A, Maeda S, Nishida K
    • Journal Title

      Invest Ophthalmol Vis Sci.

    • Related Report
      2013 Final Research Report
  • [Journal Article] Choroidal thickness in central serous chorioretinopathy2013

    • Author(s)
      Kuroda S, Ikuno Y, Yasuno Y, Nakai K, Usui S, Sawa M, Tsujikawa M, Gomi F, Nishida K
    • Journal Title

      Retina

    • Related Report
      2013 Final Research Report
  • [Journal Article] Choroidal thickness in central serous chorioretinopathy.2013

    • Author(s)
      Kuroda S, Ikuno Y, Yasuno Y, Nakai K, Usui S, Sawa M, Tsujikawa M, Gomi F, Nishida K.
    • Journal Title

      Retina

      Volume: epub-ahead Issue: 2 Pages: 302-8

    • DOI

      10.1097/iae.0b013e318263d11f

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal observations in Vogt-Koyanagi -Harada disease using high-penetration optical coherence tomography2012

    • Author(s)
      Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T, Ohguro N, Nishida K
    • Journal Title

      Graefes A rch Clin Exp Ophthalmol

    • Related Report
      2013 Final Research Report
  • [Journal Article] Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography.2012

    • Author(s)
      Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T, Ohguro N, Nishida K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 250 Issue: 7 Pages: 1089-95

    • DOI

      10.1007/s00417-011-1910-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography2012

    • Author(s)
      Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T, Ohguro N, Nishida K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: (Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Broad spectrum antiangiogenic treatment for ocular neovascular diseases2010

    • Author(s)
      Ofra Benny, Kei Nakai, Takeru Yoshimura, Lauren Bazinet, James Akula, Nakao Shintaro, Ali Hafezi-Moghadam, Dipak Panigrahy, Pouya Pakneshan, Robert J. D'Amato
    • Journal Title

      PLoS One

    • Related Report
      2013 Final Research Report
  • [Journal Article] Broad spectrum antiangiogenic treatment for ocular neovascular diseases.2010

    • Author(s)
      Ofra Benny, Kei Nakai, Takeru Yoshimura, Lauren Bazinet, James Akula, Nakao Shintaro, Ali Hafezi-Moghadam, Dipak Panigrahy, Pouya Pakneshan, Robert J.D'Amato
    • Journal Title

      PLoS One.

      Volume: Vol.5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses2010

    • Author(s)
      Satoshi Hohki, Nobuyuki Ohguro, Hiroshi Haruta, Kei Nakai, Fumitaka Terabe, Satoshi Serada, Minoru Fujimoto, Shintaro Nomura, Hirohisa Kawahata, Tadamitsu Kishimoto, Tetsuji Naka
    • Journal Title

      Exp Eye Res

      Volume: Vol.91 Pages: 162-70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 樹状細胞の脈絡膜新生血管への作用日本眼炎症学会学術奨励賞受賞2011

    • Author(s)
      中井慶
    • Organizer
      第45回日本眼炎症学会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 長波長光源を用いた高侵達光干渉断層計による脈絡膜骨腫の観察2010

    • Author(s)
      中井慶、生野恭司、安野嘉晃、大黒伸行、西田幸二
    • Organizer
      第64回 日本臨床眼科学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児ぶどう膜炎におけるメトトレキセート内服の治療効果2010

    • Author(s)
      佐々木有紀子、中井慶、大黒伸行
    • Organizer
      第44回 眼炎症学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Choroidal Observations in Sunset Glow Fundi of Vogt-Koyanagi-Harada Disease Using High-Penetration Optical Coherence Tomography2010

    • Author(s)
      Kei Nakai, Yasushi Ikuno, Yoshiaki Yasuno, Takeyoshi Nouchi, Nobuyuki Ohguro
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      フロリダ、アメリカ
    • Year and Date
      2010-05-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 樹状細胞の脈絡膜新生血管への作用2010

    • Author(s)
      中井慶, 大黒伸行, Ofer Fainaru, Robert J.D'Amato
    • Organizer
      第114回 日本眼科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 樹状細胞の脈絡膜新生血管への作用

    • Organizer
      第45回日本眼炎症学会 日本眼炎症学会学術奨励賞 受賞
    • Related Report
      2013 Final Research Report
  • [Presentation] R Dendritic cels augment choroidal angiogenesis

    • Author(s)
      Nakai K, Ohguro N, Fainaru O, D'Amato
    • Organizer
      The annual Meeting of the Japanese Ophthalmological Society
    • Related Report
      2013 Final Research Report
  • [Book] なぜ真菌性眼内炎は後極部から起こり、急性網膜壊死は周辺部から起こるのか?(タイトル;眼のサイエンス 眼疾患の謎)2010

    • Author(s)
      中井慶、大黒伸行
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report
  • [Book] 眼のかすみを起こす疾患 ぶどう膜疾患2010

    • Author(s)
      中井慶、大黒伸行
    • Publisher
      メディカル葵
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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