Dendritic Cells Augment Choroidal Neovascularization
| Project/Area Number |
22791657
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAI kei 大阪大学, 医学(系)研究科(研究院), 助教 (30546883)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 脈絡膜新生血管 / 樹状細胞 / 血管新生 |
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| Research Abstract |
Age-related macular degeneration is the leading cause of irreversible vision loss among the elderly in most industrialized nations.Severe vision loss in ARMD is most commonly caused by choroidal neovascularization, wherein new vessels from the choroid invade the subretinal space through Bruch membrane.Dendritic cells are innate immune cells of hematopoietic origin that have a pivotal role in the initiation of the adaptive immune response.Although DCs have been detected in normal uvea, inflamed retina and drusen deposits, to date there has been no reports of their presence in CNV.Aside from their role in immune function, DCs have recently been shown to support angiogenesis in tumors, endometriosis and lymph nodes.We showed that DCs may play a role in the pathogenesis of CNV similar to their role in tumor growth and endometriosis.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses2010
Author(s)
Satoshi Hohki, Nobuyuki Ohguro, Hiroshi Haruta, Kei Nakai, Fumitaka Terabe, Satoshi Serada, Minoru Fujimoto, Shintaro Nomura, Hirohisa Kawahata, Tadamitsu Kishimoto, Tetsuji Naka
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Journal Title
Exp Eye Res
Volume: Vol.91
Pages: 162-70
Related Report
Peer Reviewed
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