| Project/Area Number |
22791670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
INOMATA Yasuya 熊本大学, 大学院・生命科学研究部, 助教 (50452884)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 加齢黄斑変性症 / 酸化ストレス / Nアセチルシステイン / スカベンジャー受容体 / N-acetyl-cystein / 脈絡膜新生血管 / N-acetyl-cysteine / スカベンジー受容体 |
|---|
| Research Abstract |
Our previous studies have suggested that the anti-oxidant, such as thioredoxin, and pitavastatin, could inhibit the development of choroidal neovascularization(CNV). We reported that N-Acetyl-cystein(NAC), which has a tissue protective action against oxidative stress, inhibited indicators of oxidative stress and the activation of NF-
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