functional analyses of Angptl2 in pathogenesis of diabetic retinopathy

• Project/Area Number: 22791671
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kumamoto University
• Principal Investigator: ITO Yasuhiro 熊本大学, 医学部附属病院, 助教 (70380996)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 眼生化学 / 分子生物学 / 糖尿病網膜症

Research Abstract

Concentration of Angptl2 in vitreous of patients with proliferative diabetic retinopathy was increased compared to the control, and Angptl2 expression was found in fibrovascular membrane of proliferative diabetic retinopathy. Moreover, IL-6, MCP-1, ICAM-1 and VCAM-1 expression was decreased in Angptl2 knockout mice compared to the control, and leukocyte adhesion to endothelial cells was suppressed in Angptl2 knockout mice.

Research Products

• [Journal Article] Frequency and Risk Factors for Neovascular Glaucoma After Vitrectomy in Eyes With Proliferative Diabetic Retinopathy (2012)
  • Author(s): Goto Aakiko, Inatani Masaru, Inoue Toshio, Awai-Kasaoka Nanako, Takihara Yuji, Ito Yasuhiro, Fukushima Mikiko, Tanihara Hidenobu
  • Journal Title: J Glaucoma Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Blood vessel endothelial VEGFR-2 delays lymphangiogenesis : an entrapping mechanism links lymph- and angiogenesis (2011)
  • Author(s): Nakao S, Zandi S, Hata Y, Kawahara S, Arita R, Schering A, Sun D, Melhorn MI, Ito Y, Lara-Castillo N, Ishibashi T, Hafezi-Moghadam A
  • Journal Title: Blood Volume: 117 Pages: 1081-90
  • Peer Reviewed
• [Presentation] Angptl2 Knockout Mice Suppress Inflammation In Retinal Vessels Induced By A High-fat Diet (2012)
  • Author(s): Yasuhiro Ito, Yuichi Oike, Hidenobu Tanihara
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: Broward County Convention Center(Greater Fort Lauderdale, Florida, USA)
  • Year and Date: 2012-05-08
• [Presentation] Increased Intraocular Level of Angiopoietin-like protein 2 in Diabetic Retinopathy (2011)
  • Author(s): Yasuhiro Ito, Mikiko Fukushima, Hidenobu Tanihara
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2011-10-24
• [Presentation] Increased Intraocular Level of Angiopoietin-like protein 2 in Diabetic Retinopathy (2011)
  • Author(s): Yasuhiro Ito, Mikiko Fukushima, Hidenobu Tanihara
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-10-24
• [Presentation] Adiponectin Suppresses Adherent Leukocytes in Retinal Vessels Induced by High-Fat Diet (2011)
  • Author(s): Yasuhiro Ito, Shintaro Nakao, Y.Okamoto, S.Zandi, Hidenobu Tanihara
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2011-05-05
• [Presentation] Angptl2 Induces Inflammation of Retinal Vessels in Diabetes (2010)
  • Author(s): Yasuhiro Ito, Yuji Takihara, Mikiko Fukushima, Masaru Inatani, Yuichi Oike Hidenobu Tanihara
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: Broward County Convention Center(Greater Fort Lauderdale, Florida, USA)
  • Year and Date: 2010-05-06
• [Presentation] 増殖糖尿病網膜症における硝子体中のAngptl2の濃度 (2010)
  • Author(s): 伊藤康裕、福島美紀子、犬丸淳子、宮崎智成、後藤信祐、尾池雄一、谷原秀信
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2010-04-15