The evaluation of the marker genes during the development of trabecular meshwork cells and the induction of trabecular meshwork cells from human iPS cells
Project/Area Number |
22791678
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
UENO Morio 京都府立医科大学, 医学研究科, 助教 (40426531)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 眼発生 / 再生医学 / 再生医療 |
Research Abstract |
Transplantation of trabecular meshwork cells to the damaged trabecular meshwork tissues in patients of primary open angle glaucoma because one of causes of primary open angle glaucoma is the decrement of trabecular meshwork cells. In this study, we performed the development of the induction system of human trabecular meshwork cells from human induced pluripotent stem cells to mimic the in vivo development of trabecular meshwork tissues.
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese2012
Author(s)
Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Omi N, Ueno M, Imai K, Adachi H, Kageyama M, Mori K, Kinoshita S, Tashiro K
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Journal Title
Related Report
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[Journal Article] Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells2010
Author(s)
Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y
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Journal Title
Cell Stem Cell
Volume: 7(2)
Pages: 225-39
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[Journal Article] Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells2010
Author(s)
Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y.
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Journal Title
Cell Stem Cell
Volume: 7
Pages: 225-239
Related Report
Peer Reviewed
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[Presentation] カスタムチップによる既知緑内障遺伝子解析2010
Author(s)
池田陽子, 森和彦, 上野盛夫, 今井浩二郎, 大見奈津江, 不破正博, 中野正和, 八木知人, 徳田雄市, 田代啓, 木下茂
Organizer
第21回日本緑内障学会
Place of Presentation
博多
Year and Date
2010-09-25
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[Presentation] 原発開放隅角緑内障疾患マーカーSNPsと全身疾患の関連性の検討2010
Author(s)
池田陽子, 森和彦, 上野盛夫, 今井浩二郎, 八木知人, 大見奈津江, 徳田雄市, 不破正博, 田中雅深, 田代啓, 木下茂
Organizer
第114回日本眼科学会総会
Place of Presentation
名古屋
Year and Date
2010-04-15
Related Report
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