A new treatment for choroidal, retinal and corneal neovascularization with targeting to alfa-9 integrin ligand

• Project/Area Number: 22791680
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Wakayama Medical University
• Principal Investigator: FUJITA Norihito 和歌山県立医科大学, 医学部, 博士研究員 (10453177)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: α９インテグリン / 血管新生 / 脈絡膜 / 角膜 / 網膜 / α9インテグリン

Research Abstract

This study provide evidence that endogenous alfa-9 integrin ligand including osteopontin or tenascin-C at physiological levels inhibits induced angiogenesis in laser-induced choroidal neovascularization (CNV) in vivo. Mechanism of action might include the effects of alfa-9 integrin ligand on vascular endothelial cells. Blocking alfa-9 integrin ligand activity might be a potential strategy for the prevention or treatment of CNV in an age-related macular degeneration (AMD) patient. A clinical trial by using antibody is to be set up for establishment of a new AMD treatment strategy.

Research Products

• [Journal Article] Impaired cornea wound healing in a tenascin C-deficient mouse model (2012)
  • Author(s): Sumioka T, Kitano A, Flanders KC, Okada Y, Yamanaka O, Fujita N, Iwanishi H, Kao WW, Saika S
  • Journal Title: Lab Invest Volume: 93(2) Issue: 2 Pages: 207-17
  • DOI: 10.1038/labinvest.2012.157
  • Peer Reviewed
• [Journal Article] Endogenous osteopontin involvement in laser-induced choroidal neovascularization in mice (2011)
  • Author(s): Fujita N, Fujita S, Ogata N, Matsuoka M, Okada Y, Kon S, Uede T, Saika S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 52(13) Pages: 9310-5
  • Peer Reviewed
• [Journal Article] Impaired angiogenic response in the cornea of mice lacking tenascin C (2011)
  • Author(s): Sumioka T, Fujita N, Kitano A, Okada Y, Saika S
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 52(5) Pages: 2462-7
• [Journal Article] Endogenous osteopontin involvement in laser-induced choroidal neovascularization in mice (2011)
  • Author(s): Fujita N, Fujita S, Ogata N, et.al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 9130-9135
  • Peer Reviewed
• [Journal Article] Impaired angiogenic response in the cornea of mice lacking osteopontin (2010)
  • Author(s): Fujita N, Fujita S, Okada Y, et.al
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 50 Pages: 790-794
  • Peer Reviewed
• [Presentation] Roles of osteopontin in development of choroidal neovascularization in mice (2010)
  • Author(s): Norihito Fujita, Yuka Okada, Toshimitsu Uede, et.al
  • Organizer: ARVO
  • Place of Presentation: Florida, USA
  • Year and Date: 2010-05-04
• [Presentation] NOS2欠損マウスにおける脈絡膜神経血管の遺伝子発現
  • Author(s): 藤田識人, 岡田由香, 雑賀司珠也
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] テネイシン C欠損マウスにおける角膜創傷治癒の障害
  • Author(s): 住岡孝吉, 田中才一, 泉谷愛, 藤田識人, 岡田由香, 雑賀司珠也
  • Organizer: テネイシンフォーラム
• [Presentation] The role of Extracellular Matrix Components in Corneal Neovascularization : Osteopontin and Tenascin C
  • Author(s): Fujita N, Sumioka T, Okada Y, Saika S
  • Organizer: 2011 Korea-Japan Joint Cornea Conference
  • Place of Presentation: Seoul
• [Presentation] Impaired Angiogenic Response and Wound Healing in the Cornea of Mice Lacking Tenascin C
  • Author(s): Sumioka S, Fujita N, Kitano A, Okada Y, Saika S
  • Organizer: 第10回オステオポンチン研究会
  • Place of Presentation: 札幌
• [Presentation] Loss of nitric oxide synthase type II inhibits formation of corneal neovascularization and Argon laser-induced choroidal neovascularization in mice
  • Author(s): Fujita N, Nishimoto S, Miyamoto T, Okada Y, Saika S
  • Organizer: ARVO
  • Place of Presentation: Florida, USA
• [Presentation] NOS2欠損マウスにおける脈絡膜神経血管の動態
  • Author(s): 藤田識人, 岡田由香, 雑賀司珠也
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Impaired angiogenic response in cornea by lacking tenascin C in mice
  • Author(s): Sumioka T, Kitano A, Fujita N, Okada Y, Saika S
  • Organizer: ARVO
  • Place of Presentation: Florida, USA
• [Presentation] Roles of osteopontin in development of choroidal neovascularization in mice
  • Author(s): Fujita N, Okada Y, Uede T, Matsuoka M, Ogata N, Miyajima M, Saika S
  • Organizer: ARVO
  • Place of Presentation: Florida, USA
• [Presentation] 角膜創傷治癒過程での角膜血管新生におけるテネイシン C の役割
  • Author(s): 住岡孝吉, 岡田由香, 藤田識人, 北野愛, 雑賀司珠也
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 脈絡膜血管新生に対するオステオポンチンの作用の検討
  • Author(s): 藤田識人, 岡田由香, 上出利光, 松岡雅人, 緒方奈保子, 雑賀司珠也
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 細胞外マトリックスによる血管新生制御 : 角膜と脈絡膜
  • Author(s): 藤田識人, 岡田由香, 上出利光, 松岡雅人, 緒方奈保子, 雑賀司珠也
  • Organizer: 第12回ボーダレス眼科臨床研究会
  • Place of Presentation: 大阪