Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Research Abstract |
Acute respiratory distress syndrome (ARDS) model induced by Lipopolysaccharide (LPS) was established. Thalidomide administration made Wet to dry ratio of lung (W/D) and Albumin leakage into Bronchoalveolar lavage fluid (BALF) increased. Against our hypothesis, Thalidomide doesn’t only treat ARDS, but also could advance it. We examined other anti- angiogenesis agents (Omegaven and Propofol). They also didn’t improve indexes of lung injury. We concluded that the three anti-angiogenesis agents don’t improve ARDS.
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