Role of extracellular ATP in the pathogenesis of ventilator-induced lung injury

Research Project

Project/Area Number	22791753
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	MATSUYAMA Hiroki 京都府立医科大学, 医学研究科, 助教 (80515289)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	人工呼吸関連肺損傷 / 人工呼吸 / ARDS / ATP / 肺損傷 / 細胞外ATP
Research Abstract	We investigated the role of extracellular ATP in ventilator-induce lung injury .Extracellular ATP increased with the increase in tidal volume of mechanical ventilation. The increase of ATP in the sepsis model mice tended to be larger than that in the healthy mice, suggesting that ATP had some role in the inflammatory reaction in VALI. It was not fully examined whether the inhibition of ATP could improve the VALI.