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Research of cementum and bone formation in phosphate pyrophosphate imbalance condition

Research Project

Project/Area Number 22791764
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

SATO Sunao  大阪大学, 大学院・歯学研究科, 講師 (70335660)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsリン酸 / ピロリン酸 / セメント質 / 骨 / PC-1遺伝子 / PC-1
Research Abstract

The aim of this study was to examine the effect of Pi/ PPi imbalance on gene expression in tissues associated with periodontal tissues, i. e., osteoblasts and cementoblasts, in vivo. Incisors and molars obtained from mice with PC-1 mutations were examined at the light microscopic level with immunohistochemical staining. Histological observations indicated that not only the molars but also the incisors from PC-1 mutant mice showed a marked increase in the amount of cementum when compared to wild-type. Immunohistochemical observation indicated that cementoblasts in wild-type showed high PC-1 expression compared to osteoblast and osteoblasts in PC-1 mutant mice showed high Osteopontin expression compared to wild-type osteoblast. These results suggest that functional changes in proteins such as PC-1, by affecting Pi/ PPi ratio, may in turn affect mineralized tissue formation by altering expression of key genes and associated proteins in osteoblasts and cementoblasts, and further, may impact differentiation potential in follicle cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2010

All Presentation (4 results)

  • [Presentation] Effects of inorganic phosphate on the dento-alveolar complex, in situ and in vitro2010

    • Author(s)
      Y. Yamamoto, S. Sunao et al
    • Organizer
      ASBMR 2010 Annual Meeting
    • Place of Presentation
      Toronto(Canada)
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸・ピロリン酸バランスの変化による歯周組織への影響2010

    • Author(s)
      山元有理、佐藤淳ら
    • Organizer
      第52回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸・ピロリン酸バランスの変化による歯周硬組織への影響2010

    • Author(s)
      山元有理、佐藤淳、岸野万伸, ら
    • Organizer
      第52回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of inorganic phosphate on the dento-alveolar complex, in situ and in vitro.2010

    • Author(s)
      Y.Yamamoto, S.Sunao, et al
    • Organizer
      ASBMR 2010 Annual Meeting
    • Place of Presentation
      Toronto (Canada)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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